Gas6（Growth arrest-specific protein 6）是维生素K依赖性蛋白，最早于1988年在小鼠胚胎纤维母细胞中发现，其生物学功能是通过与 TAM受体 相互作用来介导的。 TAM受体属于受体酪氨酸激酶家族，目前已经确定的Gas6受体包括 Tyro3 、Axl和 Mer ，其中Axl与Gas6亲和力最高。

Growth arrest – specific 6, also known as GAS6, is a human gene coding for the GAS6 protein. It is similar to the Protein S with the same domain organization and 43% amino acid identity. It was originally found as a gene upregulated by growth arrested fibroblasts.

2024年12月25日 · GAS6 (Growth Arrest Specific 6) is a Protein Coding gene. Diseases associated with GAS6 include Mesangial Proliferative Glomerulonephritis and Lupus Erythematosus. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and GPCR Pathway.

2021年3月8日 · GAS6（Growth arrest-specific protein 6）是一个75kDa的可溶性糖蛋白，最早于1988年在小鼠胚胎纤维母细胞中发现。 其下游受体被称为TAM受体，属于受体酪氨酸激酶家族，目前已经确定的GAS6受体包括TYRO3、AXL和MER。 GAS6与其受体结合后，激活受体酪氨酸激酶活性，通过下游信号转导途径，在细胞增殖、存活、黏附、迁移、自噬、侵袭、血管生成、血小板聚集和NK细胞分化等方面发挥重要作用。 GAS6/TAM受体相互作用信号通路图（选 …

GAS6 (growth arrest-specific 6) belongs structurally to the family of plasma vitamin K-dependent proteins. GAS6 has a high structural homology with the natural anticoagulant protein S, sharing the same modular composition and having 40% sequence identity.

在 MФs 中组成型表达的 efferocytotic 受体（ Tyro3 、Axl 和 Mer ）与分泌的配体 Gas6 结合，Gas6 将 MФ 表达的 TAM 受体与凋亡细胞表面的磷脂酰丝氨酸连接起来以触发 efferocytosis。作者观察到在 LPS 攻击后炎症消退阶段，AMФs 中 Gas6 的表达增加（图 1B），并且 BMMФs 的 …

Our data propose GAS6 as an independent predictor of poor survival, suggesting GAS6, both on the mRNA and on the protein level, as a potential biomarker for ovarian cancer. Gas6 was uniquely upregulated in either endothelial/mesangial cells or podocytes in IgA nephropathy.

GAS6 is a vitamin K-dependent protein abundantly expressed in fibroblasts 3T3 cells induced by growth inhibition under serum starvation conditions (6). Sequencing of the Gas6 protein by Manfioletti and colleagues revealed Gas6 is a secreted protein containing 678 amino acids with a molecular weight of 75 kDa (5, 6).

2017年3月23日 · Gas6 has a critical role in the development of multiple types of cancers, including pancreatic, prostate, oral, ovarian and renal cancers. Acute myelocytic leukaemia (AML) is a Gas6-dependent...

Axl binds to a high affinity ligand growth arrest specific 6 (Gas6) that belongs to the vitamin K-dependent family of proteins. The Gas6/Axl signaling pathway has been implicated to promote progression, metastasis, immune evasion, and therapeutic resistance in many cancer types.