下一代肿瘤免疫治疗新靶点：GAS6/AXL - 知乎 - 知乎专栏
Gas6（Growth arrest-specific protein 6）是维生素K依赖性蛋白，最早于1988年在小鼠胚胎纤维母细胞中发现，其生物学功能是通过与 TAM受体 相互作用来介导的。 TAM受体属于受体酪氨酸 …
GAS6 - Wikipedia
Growth arrest – specific 6, also known as GAS6, is a human gene coding for the GAS6 protein. It is similar to the Protein S with the same domain organization and 43% amino acid identity. It …
GAS6 Gene - GeneCards | GAS6 Protein | GAS6 Antibody
2024年12月25日 · GAS6 (Growth Arrest Specific 6) is a Protein Coding gene. Diseases associated with GAS6 include Mesangial Proliferative Glomerulonephritis and Lupus …
GAS6/TAM 信号通路：值得期待的下一代肿瘤治疗靶点 - 雪球
2021年3月8日 · GAS6（Growth arrest-specific protein 6）是一个75kDa的可溶性糖蛋白，最早于1988年在小鼠胚胎纤维母细胞中发现。 其下游受体被称为TAM受体，属于受体酪氨酸激酶家 …
Growth arrest-specific gene 6 (GAS6). An outline of its role in ...
GAS6 (growth arrest-specific 6) belongs structurally to the family of plasma vitamin K-dependent proteins. GAS6 has a high structural homology with the natural anticoagulant protein S, …
四图发PNAS丨STAT6诱导巨噬细胞中Gas6 的表达以清除凋亡的中 …
在 MФs 中组成型表达的 efferocytotic 受体（ Tyro3 、Axl 和 Mer ）与分泌的配体 Gas6 结合，Gas6 将 MФ 表达的 TAM 受体与凋亡细胞表面的磷脂酰丝氨酸连接起来以触发 efferocytosis …
GAS6 growth arrest specific 6 [ (human)] - National Center for ...
Our data propose GAS6 as an independent predictor of poor survival, suggesting GAS6, both on the mRNA and on the protein level, as a potential biomarker for ovarian cancer. Gas6 was …
Gas6/AXL pathway: immunological landscape and therapeutic …
GAS6 is a vitamin K-dependent protein abundantly expressed in fibroblasts 3T3 cells induced by growth inhibition under serum starvation conditions (6). Sequencing of the Gas6 protein by …
Molecular insights of Gas6/TAM in cancer development and therapy
2017年3月23日 · Gas6 has a critical role in the development of multiple types of cancers, including pancreatic, prostate, oral, ovarian and renal cancers. Acute myelocytic leukaemia …
Therapeutic Targeting of the Gas6/Axl Signaling Pathway in Cancer
Axl binds to a high affinity ligand growth arrest specific 6 (Gas6) that belongs to the vitamin K-dependent family of proteins. The Gas6/Axl signaling pathway has been implicated to promote …