Corticosteroids and risk of gastrointestinal bleeding: a …
Corticosteroid use was associated with increased risk of gastrointestinal bleeding and perforation. The increased risk was statistically significant for hospitalised patients only. For patients in ambulatory care, the total occurrence of bleeding or perforation was very low, and the increased risk was not statistically significant.
Bowel perforation in steroid-treated patients - PubMed
Gastrointestinal perforation in patients receiving glucocorticosteroid (GCS) therapy has been reported to have mortality rates as high as 100%. From 79 patients seen during a nine-year period, three groups were formed according to GCS dosage: group 1 (steroid perioperative coverage), group 2 (low-do …
Factors Associated with Gastrointestinal Perforation in a Cohort …
GI perforation is a rare but serious condition that affects patients with RA, most frequently in the lower GI tract. Clinicians should be aware of risk factors for GI perforation when managing RA patients, including age, history of diverticulitis, and use of glucocorticoids or NSAIDs.
Bowel perforation in steroid-treated patients. - PubMed Central …
Gastrointestinal perforation in patients receiving glucocorticosteroid (GCS) therapy has been reported to have mortality rates as high as 100%. From 79 patients seen during a nine-year period, three groups were formed according to GCS dosage: group ...
(PDF) Corticosteroids and risk of gastrointestinal bleeding: A ...
2014年5月2日 · Corticosteroids increased the risk of gastrointestinal bleeding or perforation by 40% (OR 1.43, 95% CI 1.22 to 1.66). The risk was increased for hospitalised patients (OR 1.42, 95% CI 1.22 to...
In total, 804 (2.4%) patients had a gastrointestinal bleeding or perforation (2.9% and 2.0% for corticosteroids and placebo). Corticosteroids increased the risk of gastrointestinal bleeding or perforation by 40% (OR 1.43, 95% CI 1.22 to 1.66). The risk was increased for hospitalised patients (OR 1.42, 95% CI. 1.22 to 1.66).
Adrenocorticotropic Hormone-Dependent Cushing's Syndrome …
2023年11月1日 · Herein, we describe the medical history, physical examination, and investigatory findings of a 30-year-old female with a recent diagnosis of ACTH-dependent Cushing's syndrome that was complicated by gastric ulcer perforation, necessitating an urgent exploratory laparotomy.
Perforated peptic ulcer: use of pre‐admission oral glucocorticoids …
2005年12月13日 · Use of oral glucocorticoids has been associated with severe gastrointestinal side effects, including peptic ulcer and peptic ulcer perforation. Strong evidence now exists that glucocorticoids alone or in combination with other ulcer‐related drugs increase the risk of complicated peptic ulcer disease (PUD). 2 - 5
Physiological, Pharmacological and Pathological Actions of ...
1981年9月1日 · Perforation of the intestine in patients on glucocorticoids may be masked because the signs of peritonitis are suppressed. Absorption of oral glucocorticoids is from the jejunum and is not impaired by severe mucosal disease.
Corticosteroids and risk of gastrointestinal bleeding: a systematic ...
Corticosteroids increased the risk of gastrointestinal bleeding or perforation by 40% (OR 1.43, 95% CI 1.22 to 1.66). The risk was increased for hospitalised patients (OR 1.42, 95% CI 1.22 to 1.66). For patients in ambulatory care, the increased risk was not statistically significant (OR 1.63, 95% CI 0.42 to 6.34).