2024年1月1日 · In this article, Brivanlou and colleagues show that stem cell-derived blastocyst models, blastoids, self-organize a BRA + population and undergo gastrulation in 7–10 days …

2024年1月9日 · Here we show that upon in vitro attachment, human blastoids self-organize a BRA + population and undergo gastrulation. Single-cell RNA sequencing of these models …

2025年1月14日 · In this study, we developed a high-fidelity blastoid model using 4 chemicals + leukemia inhibitory factor (LIF) (4CL) naive human pluripotent stem cells (hPSCs) (4CL …

2019年10月15日 · During gastrulation, the pluripotent epiblast self-organizes into the 3 germ layers-endoderm, mesoderm and ectoderm, which eventually form the entire embryo. …

Gastrulation begins several days after the fertilization of an egg in species like mice and humans. In those intervening days after fertilization (but before gastrulation), the egg undergoes several …

2023年5月17日 · Here we show that human blastoids break symmetry and undergo gastrulation upon in vitro attachment. scRNA-seq of these models replicate the transcriptomic signature of …

Discuss how the process of gastrulation transforms the blastula into an embryo, called gastrula with three germ layers. Differentiate the process of gastrulation among eggs with varying …

2023年12月18日 · Here, we provide an overview of the latest research on interspecies developmental control across mammals. This includes single-cell atlases of several …

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Single-cell RNA sequencing of these models replicates the tran-scriptomic signature of the human gastrula. Analysis of developmental timing reveals that in both blastoid models and natural …