2023年5月23日 · Logic gating is a strategy for chimeric antigen receptor (CAR) T cell therapy to target tumor cells that lack tumor-specific antigens and prevent on-target/off-tumor toxicity. In …

2023年3月15日 · 通过利用本地T细胞信号生物学的优势，实现一个高度特异和可移植的系统，以限制T细胞对双抗原相遇的反应。其他几个AND-gate CAR系统已经被设计出来，包括SynNotch …

2023年4月3日 · Improving the clinical efficacy of CAR T cell therapies will require engineering T cells that overcome heterogeneous and low-abundance target expression while minimizing …

2016年2月11日 · These dual-receptor AND-gate T cells are only armed and activated in the presence of dual antigen tumor cells. These T cells show precise therapeutic discrimination in …

Logic gating is a strategy for chimeric antigen receptor (CAR) T cell therapy to target tumor cells that lack tumor-specific antigens and prevent on-target/off-tumor toxicity. In a recent...

2020年7月30日 · Chimeric antigen receptors (CARs) are synthetic receptors that enable T cells to recognize tumor-associated antigens (TAAs) in a major histocompatibility complex (MHC) …

In this review, we introduce the concept of biological logic gating and how this technology addresses some of the challenges of current CAR T treatment. We outline the types of logic …

Several CD8+ T-cell subsets, such as interleukin-17-producing and follicular CXCR5+ CD8+ T-cells, could play a particular role during HIV infection by promoting the gut barrier integrity, and...

2025年1月16日 · We show that CD8 + T-cell-specific deletion of Trim28 in mice disrupts autocrine IL-2 production and leads to impaired CD8 + T cell activation in vitro and in vivo. …

Download scientific diagram | CD27/28-CD57+ T cells and their CD27/28+ counterparts were isolated from the peripheral blood and tumor tissue of HNSCC patients. (a) Flow cytometry …