2021年2月9日 · Here, we investigate the role of Plasmodium falciparum guanylyl cyclase alpha (GCα) and its associated P4-ATPase module, showing that asexual blood-stage parasites lacking both the cyclase and P4-ATPase domains are unable to egress from host erythrocytes.

2023年6月16日 · We show that temperature-dependent epistatic interactions between phosphodiesterases counterbalance GCα basal activity preventing gametocyte activation before mosquito blood feed. GCα interacts with two multipass membrane cofactors in schizonts and gametocytes: UGO (unique GC organizer) and SLF (signaling linking factor).

2023年1月29日 · Recently, a membrane protein gametogenesis essential protein 1 (GEP1) was found to be responsible for sensing these signals and interacting with a giant guanylate cyclase α (GCα) to activate the cGMP-PKG-Ca 2+ signaling pathway for malaria parasite gametogenesis. However, the molecular mechanisms for this process remain unclear.

2020年4月9日 · GEP1 interacts with GCα, a cGMP synthesizing enzyme in gametocytes. Both GEP1 and GCα are expressed in cytoplasmic puncta of both male and female gametocytes. Depletion of GCα impairs...

2023年1月29日 · Membrane-anchored guanylyl cyclase GCα has been revealed to be responsible for cGMP synthesis during gametogenesis, and the activity and regulation of GCα require another membrane protein GEP1 and upstream signals, including temperature change, pH change, and a tryptophan metabolism intermediate xanthurenic acid (XA) . However, the structure ...

2022年7月22日 · In the malaria parasite Plasmodium falciparum, guanylyl cyclase alpha (GCα) is an integral membrane protein that is essential for release (egress) of merozoites from their host erythrocytes. GCα is unusual in that it contains both a C-terminal cyclase domain and an N-terminal P4-ATPase domain of unknown function.

gcαコートは木材本来のもつ美感・品質を保ちながら更に耐摩耗性を向上した当社独自の塗装処理方法です。 グリーンカーボンを含む塗料を表面に塗布し、耐摩耗回転数を1,000回転以上にアップさせています。

2020年7月15日 · By phosphoproteomic and chemical-genetic analysis, we isolate two functional targets of Pf PP1 for egress: a HECT E3 protein-ubiquitin ligase; and GCα, a fusion protein composed of a guanylyl...

4月9日，Nature Communications杂志在线发表了我室袁晶教授题为“An intracellular membrane protein GEP1 regulates xanthurenic acid induced gametogenesis of malaria parasites”的研究论文。...

2021年1月26日 · Here, we investigate the role of Plasmodium falciparum guanylyl cyclase alpha (GCα) and its associated P4-ATPase module, showing that asexual blood-stage parasites lacking both the cyclase and P4-ATPase domains are unable to egress from host erythrocytes. GCα-null parasites cannot synthesize cGMP or mobilize calcium, a cGMP-dependent protein ...