TNIK, a Novel Member of the Germinal Center Kinase Family That ...
1999年10月22日 · Germinal center kinases (GCKs) compose a subgroup of the Ste20 family of kinases. Here we describe the cloning and characterization of a novel GCK family kinase, …
Germinal center kinases in immune regulation - Nature
2012年9月10日 · Germinal center kinases (GCKs) are a family of ‘Sterile 20 (STE20) like kinases’, which participate in both the determination of cell fate and the regulation of cell...
TNIK in disease: from molecular insights to therapeutic prospects
2024年6月9日 · It can be divided into two broad classes based on their structural characteristics: the p21-activated kinase (PAK) family and the germinal center kinase (GCK) family. The PAK …
STK25的生物学特性及其与肿瘤关系的研究进展 - zpwz.net
Germinal center kinases (GCK) are a type of serine/threonine protein kinase characterized by having a conserved serine/threonine protein-kinase domain, and together with p21-activated …
The Traf2 and NcK interacting kinase inhibitor NCB-0846 …
2024年5月1日 · The GCK family, which interacts with tumor necrosis factor (TNF)-receptor-associated factor 2 (TRAF2) and NCK adaptor protein 1 (NCK1), is a subgroup of the STE20 …
Clinical Potential of Misshapen/NIKs-Related Kinase (MINK) 1—A …
2024年12月5日 · Misshapen/NIKs-related kinase (MINK) 1 belongs to the mammalian germinal center kinase (GCK) family. It contains the N-terminal, conserved kinase domain, a coiled-coil …
TNIK, a novel member of the germinal center kinase family that
1999年10月22日 · Germinal center kinases (GCKs) compose a subgroup of the Ste20 family of kinases. Here we describe the cloning and characterization of a novel GCK family kinase, …
Molecular cloning of MINK, a novel member of mammalian GCK family ...
2000年3月3日 · A new germinal center kinase (GCK) family kinase, Misshapen/NIKs-related kinase (MINK), has been cloned and its expression has been characterized in several tissues …
Genetic testing of GCK-MODY identifies a novel pathogenic
2020年3月30日 · Glucokinase-maturity-onset diabetes of the young (GCK-MODY or MODY 2), caused by a heterozygous inactivating variant in the Glucokinase (GCK) gene, is a common …
Cloning of MASK, a Novel Member of the Mammalian Germinal …
We have cloned a novel human GCK family kinase that has been designated as MASK (Mst3 andSOK1-related kinase). MASK is widely expressed and encodes a protein of 416 amino …