2024年12月25日 · This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme.

Glucokinase regulator (GCKR) encodes glucokinase regulatory protein (GKRP), a hepatocyte-specific inhibitor of the glucose-metabolizing enzyme glucokinase (GCK). Genome-wide association studies have identified a common coding variant within GCKR associated with multiple metabolic traits.

大量研究表明，GKRP 功能障碍并不是高甘油三酯血症的唯一原因，这意味着可以通过小分子 GKRP 抑制激活肝脏特异性 GCK 来治疗 2 型糖尿病。 该综述强调了目前关于葡萄糖激酶和 GKRP 在肝糖代谢和糖尿病中的特征性作用的发现。 这些信息影响了糖尿病定向分子疗法的发展，从而提高了我们对脂质和葡萄糖生理学的理解。 葡萄糖激酶调节剂 (GCKR) 基因编码葡萄糖激酶 (GCK) 抑制剂，仅存在于肝细胞中，负责葡萄糖代谢。 在全基因组关联研究中，常见的 GCKR 编码 …

2013年1月2日 · Common genetic variants in glucokinase regulator (GCKR), which encodes GKRP, a regulator of hepatic glucokinase (GCK), influence multiple metabolic traits in genome-wide association studies (GWASs), making GCKR one of …

葡萄糖激酶 (GK) 又称 己糖激酶IV （HK-IV），其可敏锐地感知体内葡萄糖浓度的变化并启动血糖调节系统以维持血糖稳态，是人体重要的葡萄糖传感器。 GK作为葡萄糖感受器,主要特异性分布在 胰岛β细胞 和 肝细胞 中,参与糖代谢的各种途径.GK通过增加 胰岛素 释放和促进肝葡萄糖的利用双重作用机制来降低血糖,在维持血糖稳态过程中发挥重要作用。 当人体血糖升高并超过正常分为内, 葡萄糖转运蛋白2 会将葡萄糖转运至胰岛β细胞中,而后由GK将葡萄糖磷酸化6-磷酸葡萄糖进入 …

2024年6月29日 · Using publicly available genome-wide association study summary statistics, we selected independent genetic variants of GCKR and GCK associated with fasting plasma glucose (FPG) as instrumental variables, to mimic the effects of impaired GK-GKRP interaction and direct GK activation, respectively.

2010年7月23日 · Single nucleotide polymorphisms (SNPs) from GCK, GCKR, G6PC2 and MTNR1B were found to modulate the fasting glucose levels. The current study aimed to replicate this association in the Chinese population and further analyze their effects on …

2018年10月30日 · The rs780094 single nucleotide polymorphism (SNP; C/T) of glucokinase regulatory protein gene (GCKR) is a regulatory genetic variant that has been associated with lactate levels in the fasting...

2022年11月1日 · The activity of GCK in hepatocytes is regulated by glucokinase regulatory protein (GKRP, gene symbol GCKR) which acts as a negative regulator by sequestering GCK within the nucleus when prevailing blood glucose is low [8].

The glucokinase regulator (GCKR) gene encodes an inhibitor of the glucokinase enzyme (GCK), found only in hepatocytes and responsible for glucose metabolism. A common GCKR coding variation has been linked to various metabolic traits in genome-wide association studies.