Targeting the GCK pathway: a novel and selective therapeutic …
2021年4月1日 · We identified germinal center kinase (GCK) as a novel therapeutic target in MM with RAS mutation. GCK knockdown (KD) in MM cells demonstrated in vitro and in vivo that …
Gck Inhibition Is a Novel Therapeutic Strategy for RAS Mutated …
2020年11月5日 · Therefore, key component in the RAS/MAPK pathway may represent an alternative therapeutic target for MM. Germinal center kinase (GCK), also named mitogen …
Pathophysiological significance and therapeutic targeting of …
2016年7月14日 · In summary, we show that the GCK pathway is activated in DLBCL and promotes the proliferation and survival of these tumors. We demonstrate that both RNA …
Blood：靶向GCK通路：治疗RAS突变型MM的一种新选择性@MedSci
2020年10月11日 · 研究人员发现， 生发中心激酶 (GCK)是RAS突变型MM的一个新的治疗靶点 。 敲除GCK基因的MM细胞的体内外实验结果表明， 沉默GCK可抑制MM细胞的生长，阻 …
Gck Kinase Activity Is Critical for RAS Mutated Myeloma
2019年11月13日 · Given the upstream activator role of Germinal Center Kinase (GCK) in the MAPK pathway, GCK might be an attractive therapeutic target in MM. Indeed, we recently …
Targeting the GCK pathway: a novel and selective therapeutic strategy ...
2021年4月1日 · We identified germinal center kinase (GCK) as a novel therapeutic target in MM with RAS mutation. GCK knockdown (KD) in MM cells demonstrated in vitro and in vivo that …
Targeting the GCK pathway: a novel and selective therapeutic …
2021年4月4日 · Germinal center kinase (GCK), also called MAPK kinase kinase kinase 2 (MAP4K2), has emerged as a crucial potential player in the regulation of stress-activated …
Gck Kinase Activity Is Critical for RAS Mutated Myeloma - a …
2019年11月13日 · Given the upstream activator role of Germinal Center Kinase (GCK) in the MAPK pathway, GCK might be an attractive therapeutic target in MM. Indeed, we recently …
Germinal center kinases in immune regulation - Nature
2012年9月10日 · Germinal center kinases (GCKs) participate in a variety of signaling pathways needed to regulate cellular functions including apoptosis, cell proliferation, polarity and...
Glucokinase (GCK) in diabetes: from molecular mechanisms to …
2024年9月8日 · This review offers a comprehensive exploration of the critical role played by the GCK gene in diabetes development, shedding light on its expression patterns, regulatory …