2018年11月1日 · Gamma conglutin administration lowered serum glucose concentration by 17.7%, slightly increased Slc2a2 and Pdx-1 mRNA levels in pancreas, up-regulated Slc2a2 expression in the liver, but it had no effect on hepatic Gck expression.

2010年5月19日 · Recently, liver X receptor alpha (LXRA, also known as NR1H3) was shown to upregulate L Gck gene expression by binding to the LXR response element (LXRE) (−52/–39 bp) in its promoter. In addition, LXRA increases L Gck gene expression by inducing SREBF1c and increasing transcriptional activity of PPARG.

2005年7月1日 · The aim of this study was to investigate whether single nucleotide polymorphisms (SNPs) in the genes regulating insulin secretion (SLC2A2 [encoding GLUT2], GCK, TCF1 [encoding HNF-1α], HNF4A, GIP, and GLP1R) are associated with the conversion from impaired glucose tolerance (IGT) to type 2 diabetes in participants of the Finnish Diabetes ...

Impaired insulin secretion is a fundamental defect in type 2 diabetes. The aim of this study was to investigate whether single nucleotide polymorphisms (SNPs) in the genes regulating insulin secretion (SLC2A2 [encoding GLUT2], GCK, TCF1 [encoding HNF-1alpha], HNF4A, GIP, and GLP1R) are associated wi …

2010年4月22日 · To determine if the Ins2, Gck, or Slc2a2 genes might be direct targets of Rfx3, we analyzed the results of a chromatin immunoprecipitation sequencing (ChIP-seq) experiment performed with Rfx3-specific antibodies and chromatin from Min6 cells. Two peaks were observed in the promoter that drives Gck expression in β-cells (Fig. 7, A).

2022年5月1日 · PXR activation reduced recruitment of HNF4 α on the Slc2a2 promoter, resulting in Slc2a2 transcriptional repression. The roles of HNF4 α in regulating GLUT2 have also been demonstrated in other cells such as pancreatic β cells and embryonic stem cells 43,44.

2018年7月1日 · Quantitative reverse transcription-polymerase chain reaction analysis revealed that glucocorticoids enhance the gene expression of not only insulin 1 but also glucose transporter-2 (Glut2; Slc2a2) and glucokinase (Gck), two molecules important for glucose sensing.

2017年1月29日 · Histological examination demonstrated improved the localization of SLC2A2 (GLUT2), and quantitative RT-PCR showed a recovery in the expression of Mafa and Gck mRNAs in the islets of βPdx1; Ins2Akita mice, suggesting that the sustained expression of Pdx1 exerts beneficial effects on β-cell function in Ins2Akita mice, at least partially through ...

e targets modulated by Pdx-1 include the solute carrier family 2 member 2 (Slc2a2/Glut2) and glucokinase (Gck). Both Slc2a2 and Gck play essential roles in glu-cose transport, insulin secretion, and glucose homeostasis (Watada et al., 1996; Waeber et l., 1996; Ahlgren et al., 1998; McKinnon and Docherty, 2001; Fujimoto and Polonsky,

Blood glucose is transported into the liver and β-cells of pancreas through solute carrier family 2 (SLC2A2, also known as GLUT2) and immediately phosphorylated by glucokinase present in the liver (LGCK) or β-cells (βGCK) which acts as a glucose sensor.