Glucokinase regulator (GCKR) encodes glucokinase regulatory protein (GKRP), a hepatocyte-specific inhibitor of the glucose-metabolizing enzyme glucokinase (GCK). Genome-wide association studies have identified a common coding variant within GCKR ...

2022年11月1日 · Using detailed genotype-phenotype data from the Hong Kong Diabetes Register (HKDR) with over 15-year follow up, we investigated associations of the GCKR polymorphism rs1260326 as well as GCK polymorphism rs1799884 with kidney outcomes (ESKD, albuminuria and rapid eGFR decline) amongst Chinese patients with type 2 diabetes.

大量研究表明，GKRP 功能障碍并不是高甘油三酯血症的唯一原因，这意味着可以通过小分子 GKRP 抑制激活肝脏特异性 GCK 来治疗 2 型糖尿病。 该综述强调了目前关于葡萄糖激酶和 GKRP 在肝糖代谢和糖尿病中的特征性作用的发现。 这些信息影响了糖尿病定向分子疗法的发展，从而提高了我们对脂质和葡萄糖生理学的理解。 葡萄糖激酶调节剂 (GCKR) 基因编码葡萄糖激酶 (GCK) 抑制剂，仅存在于肝细胞中，负责葡萄糖代谢。 在全基因组关联研究中，常见的 GCKR 编码 …

Aims: Glucokinase (GCK) and glucokinase regulatory protein (GKRP) regulate glucose and lipid metabolism. We investigated the associations of GCKR and GCK polymorphisms with kidney outcomes. Methods: Analyses were performed in a prospective cohort who were enrolled in the Hong Kong Diabetes Register between 1995 and 2017.

2009年3月1日 · GCKR is a rate-limiting factor of glucokinase (GCK), which functions as a key glycolytic enzyme for maintaining glucose homeostasis. We examined the associations of two common genetic polymorphisms of GCKR and GCK with metabolic traits in healthy Chinese adults and adolescents.

GCKR is a rate-limiting factor of glucokinase (GCK), which functions as a key glycolytic enzyme for maintaining glucose homeostasis. We examined the associations of two common genetic polymorphisms of GCKR and GCK with metabolic traits in …

GCKR 基因rs780094 (C>T)多态性基因型频率，采用实时荧光定量PCR法进行检测。 采用成组 t 检验，对2组孕妇人体质量指数 (BMI)，总胆固醇 (TC)、高密度脂蛋白胆固醇 (HDL-C)、低密度脂蛋白胆固醇 (LDL-C)、尿素浓度，以及总蛋白、白蛋白水平进行比较。 采用Mann-Whitney U 检验，对2组孕妇空腹血糖、75 g口服葡萄糖耐量试验 (OGTT) 2 h血糖、三酰甘油、肌酐、尿酸浓度进行比较。 采用 χ2 检验，对2组孕妇的妊娠期高血压疾病发生率、有糖尿病家族史所占比例， …

目标 由GCKR编码的葡萄糖激酶调节蛋白 GKRP能够对肝脏葡萄糖激酶进行急性调节，以支持代谢需求。 大型连锁不平衡区域内常见的人类GCKR rs1260326:Pro446 > Leu 变体与多效性特征相关，包括较低的 2 型糖尿病风险和升高的血液甘油三酯和胆固醇。

2022年8月31日 · Glucokinase (GCK) and glucokinase regulatory protein (GKRP) regulate glucose and lipid metabolism. We investigated the associations of GCKR and GCK polymorphisms with kidney outcomes. Analyses were performed in a prospective cohort who were enrolled in the Hong Kong Diabetes Register between 1995 and 2017.

2017年4月6日 · Single-variant association analysis interrogating 70,444 single nucleotide polymorphisms identified a novel locus, GCKR, significantly associated with circulating FGF21 levels at genome-wide significance.