2024年12月25日 · GCNT1 (Glucosaminyl (N-Acetyl) Transferase 1) is a Protein Coding gene. Diseases associated with GCNT1 include Pancreatic Cancer. Among its related pathways are O-linked glycosylation of mucins and Metabolism of proteins.

2023年10月9日 · In this study, we focus on GCNT1 (also known as C2GNT1), a glycosyltransferase enzyme that plays an essential role in the formation of core 2 branched O -glycans, an early step in O -glycan...

Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase is an enzyme that in humans is encoded by the GCNT1 gene. [5] [6] [7] This gene is a member of the beta-1,6-N-acetylglucosaminyltransferase gene family. It is essential to the formation of Gal beta 1-3(GlcNAc beta 1-6)GalNAc structures and the core 2 O-glycan ...

该基因是 β-1,6-N-乙酰葡糖胺基转移酶基因家族的成员。 它对于 Gal beta 1-3 (GlcNAc beta 1-6) GalNAc 结构和核心 2 O-聚糖分支的形成至关重要。 编码该酶的基因最初定位于 9q21，但后来定位于 9q13。 已经鉴定出编码相同蛋白质的多个可变剪接变体。 [RefSeq 提供，2008 年 7 月] This gene is a member of the beta-1,6-N-acetylglucosaminyltransferase gene family.

GCNT1 expression in prostate cancer positively correlates with cancer progression and prostate-specific antigen recurrence. Results show that ST3Gal1 uses GM130-GRASP65 and giantin, whereas C2GnT-L uses only giantin for Golgi targeting and defective giantin dimerization in PC-3 and DU145 prostate cancer cells causes fragmentation of the Golgi ...

In this study, we focus on GCNT1 (also known as C2GNT1), a glycosyltransferase enzyme that plays an essential role in the formation of core 2 branched O-glycans, an early step in O-glycan...

We show that deficiency in the glucosaminyl (N-acetyl) transferase 1 (Gcnt1), a key enzyme for core-2 O -glycans biosynthesis, drives susceptibility to Mycobacterium tuberculosis infection. The increased susceptibility of deficient mice was characterized by extensive lung immune pathology, mechanistically related to neutrophils.

2020年3月13日 · We show that deficiency in the glucosaminyl (N-acetyl) transferase 1 (Gcnt1), a key enzyme for core-2 O -glycans biosynthesis, drives susceptibility to Mycobacterium tuberculosis infection....

GCNT1 is over-expressed in prostate cancer and is associated with higher levels of core 2 O-sLe (x) in PSA, PAP and MUC1 proteins. Alterations of O-linked glycosylation could be important in prostate cancer biology and could provide a new avenue for development of prostate cancer specific glycoprotei …

2020年3月3日 · Gcnt1 is crucial for the creation of functional ligands for P- and E-selectin in leukocytes and their trafficking into some inflamed non-lymphoid tissues. In our model of MHC-mismatched allo-BMT, Gcnt1-deficient T cells could