2024年12月25日 · GDF10 (Growth Differentiation Factor 10) is a Protein Coding gene. Diseases associated with GDF10 include Prostate Cancer and Endometrial Clear Cell Adenocarcinoma. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and GPCR Pathway.

Growth differentiation factor 10 (GDF10) also known as bone morphogenetic protein 3B (BMP-3B) is a protein that in humans is encoded by the GDF10 gene. [5] GDF10 belongs to the transforming growth factor beta superfamily that is closely related to bone morphogenetic protein -3 (BMP3).

2022年3月24日 · GDF10 was downregulated in NPC owing to its aberrant promoter methylation. After treatment with 5-aza-2'-deoxycytidine, the expression of GDF10 in NPC cells was reversed. We also confirmed that the overexpression of GDF10 significantly inhibited cell proliferation and tumor growth both in vitro and in vivo, respectively.

2024年1月20日 · In this study, we investigated circulating levels of Growth Differentiation Factor 10 (GDF10), a novel regulator of adipogenesis. Previous studies report diminished circulating GDF10 levels...

GDF10 inhibits cell proliferation and epithelial-mesenchymal transition in nasopharyngeal carcinoma by the transforming growth factor-beta/Smad and NF-kappaB pathways.

2020年1月1日 · Growth differentiating factor 10 (GDF10) is a prominent member of the transforming growth factor β (TGF-β) superfamily. GDF10 regulates the cell proliferation and differentiation by utilizing the TGF-β signaling pathway. GDF10 interacts with SMAD7 to regulate the TGF-β signaling pathway.

该基因编码 TGF-β (转化生长因子-β) 蛋白质超家族的分泌配体。 该家族的配体结合各种 TGF-β 受体，导致调节基因表达的 SMAD 家族转录因子的募集和激活。 编码的前原蛋白经过蛋白水解处理，生成二硫键连接的同型二聚体的每个亚基。 这促进了中风后的神经修复。 此外，这种蛋白质可能充当肿瘤抑制因子，并且这种基因的表达减少与口腔癌有关。 [RefSeq 提供，2016 年 7 月] This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily …

2024年11月1日 · We now show a significant induction of circulating levels of growth differentiation factor 10 (GDF10) in TDAG51 −/− mice, which was of interest due to its established role as an inhibitor of osteoblast differentiation. The objective of this study was to examine the role of GDF10 in the osteogenic transdifferentiation of VSMCs.

2024年3月7日 · GDF10（Growth Differentiation Factor 10）是一种TGF-β超家族的蛋白，也被称为BMP3B（Bone Morphogenetic Protein 3B）。 它是一种密切相关的生长因子，对于细胞增殖、分化和细胞起着重要作用。

随后研究人员发现gdf10能够增强脑细胞形成新连接的能力，他们还发现了控制这一过程的信号系统。