2020年9月14日 · Background Circulating growth-differentiation factor-15 (GDF15), a cellular stress marker, abruptly increases during critical illness, but its later time course remains unclear. GDF15 physiologically controls oral intake by driving aversive responses to nutrition. Early parenteral nutrition (PN) in ICU patients has overall been shown not beneficial. We …

2022年1月6日 · A biomarker describes a measurable indicator of a patient's clinical condition that can be measured accurately and reproducibly. Biomarkers offer utility for diagnosis, prognosis, early disease recognition, risk stratification, appropriate treatment (theranostics), and trial enrichment for patients with sepsis or suspected sepsis. In this narrative review, we aim to …

2021年12月14日 · Van Dyck L, Gunst J, Casaer MP, et al. The clinical potential of GDF15 as a “ready-to-feed indicator” for critically ill adults. Crit Care. 2020;24:557. PubMed PubMed Central Google Scholar Stoppe C, Wendt S, Mehta NM, Compher C, Preiser JC, Heyland DK, et al. Biomarkers in critical care nutrition.

2025年1月28日 · Background As compared to withholding parenteral nutrition (PN) until one week after intensive care unit (ICU) admission, Early PN prolonged ICU dependency in the EPaNIC randomized controlled trial (RCT). The Refeeding RCT showed improved outcome by temporary macronutrient restriction in ICU patients developing refeeding hypophosphatemia, defined as a …

2023年7月4日 · Personalization of ICU nutrition is essential to future of critical care. Recommendations from American/European guidelines and practice suggestions incorporating recent literature are presented. Low-dose enteral nutrition (EN) or parenteral nutrition (PN) can be started within 48 h of admission. While EN is preferred route of delivery, new data highlight PN …

2011年3月22日 · High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin. Nat Med 2007, 13: 1096-1101. 10.1038/nm1629. Article CAS PubMed Google Scholar Hill SR, Carless PA, Henry DA, et al.: Transfusion thresholds and other strategies for guiding allogeneic red blood cell transfusion.