Fat mass and obesity-associated protein, also known as alpha-ketoglutarate-dependent dioxygenase FTO, is an enzyme that in humans is encoded by the FTO gene located on chromosome 16. As one homolog in the AlkB family proteins, it is the first messenger RNA (mRNA) demethylase that has been identified. [ 5 ]

2024年12月25日 · FTO (FTO Alpha-Ketoglutarate Dependent Dioxygenase) is a Protein Coding gene. Diseases associated with FTO include Growth Retardation, Developmental Delay, And Facial Dysmorphism and Lethal Polymalformative Syndrome, Boissel Type.

The fat mass and obesity-associated (FTO) gene was the first obesity-susceptibility gene identified through a genome-wide association study (GWAS). A growing number of studies have suggested that genetic variants of FTO are strongly associated with the risk of cardiovascular diseases, including hypertension and acute coronary syndrome.

In this review, we summarize the current state of knowledge on the fat mass and obesity-associated (FTO) gene and its role in obesity. The FTO-encoded protein is involved in multiple molecular pathways contributing to obesity as well as other metabolic complexities.

To date, genome-wide association studies (GWAS) have identified approximately 2,000 genetic loci with robust associations for more than 300 common traits and diseases, 4,5 including at least 75 obesity-susceptibility loci. 6,7 FTO (fat mass and obesity associated gene) was the first obesity-susceptibility gene identified through GWAS, 8,9 and ...

2020年11月16日 · In this review, we comprehensively discuss the correlation between obesity and cancer by measuring FTO gene polymorphism, as well as the molecular mechanism involved in these diseases, emphasizing FTO as the common genetic basis of obesity and cancer.

2015年9月3日 · We examined epigenomic data, allelic activity, motif conservation, regulator expression, and gene coexpression patterns, with the aim of dissecting the regulatory circuitry and mechanistic basis...

2008年3月26日 · Genome-wide association, the latest gene-finding strategy, has led to the first major success in the field of obesity genetics with the discovery of FTO (fat mass and obesity associated gene) as an obesity–susceptibility gene.

2023年12月20日 · The Fto gene, also known as fat mass and obesity-associated gene, is a gene that plays a crucial role in regulating body weight and metabolism. However, recent studies have shown that mutations in the Fto gene can also have a significant impact on brain development.

La variabilidad interindividual del gen FTO es de gran interés en la búsqueda de alelos de susceptibilidad a padecer OM. Corroboramos la asociación del SNP rs9939609 con la enfermedad, identificando en nuestra serie riesgos para los individuos con genotipo heterocigoto (T/A) y homocigoto para el cambio (A/A) (OR de 1,76 y OR de 3,28 ...