2024年12月24日 · BIK (BCL2 Interacting Killer) is a Protein Coding gene. Diseases associated with BIK include Lymphoma and Ataxia-Telangiectasia. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Busulfan Pathway, Pharmacodynamics.

Bcl-2-interacting killer is a protein that in humans is encoded by the BIK gene. [5][6][7] The protein encoded by this gene is known to interact with cellular and viral survival-promoting proteins, such as BCL2 and the Epstein–Barr virus in order to enhance programmed cell death.

2009年7月30日 · BIK is a pro-apoptotic tumor suppressor in several human tissues and its expression in cancers is prevented by chromosomal deletions encompassing the Bik locus or by...

由该基因编码的蛋白质与其他促死亡蛋白 (如 BID、BAK、BAD 和 Bax) 共享一个关键的 BH3 结构域，这是其促凋亡活性以及与 BCL2 家族的抗凋亡成员相互作用所必需的和病毒存活促进蛋白。 由于这种蛋白质的活性在存在促进生存的蛋白质的情况下受到抑制，因此建议将其作为抗凋亡蛋白质的可能靶标。 [RefSeq 提供，2011 年 9 月]

2024年11月27日 · Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins. Boyd JM, et al. Oncogene, 1995 Nov 2. PMID 7478623. BH3-only protein Bik is involved in both apoptosis induction and sensitivity to oxidative stress in multiple myeloma.

2025年2月8日 · Data indicate that methylation-induced transcriptional silencing of the BIK (bcl2-interacting killer) pro-apoptotic gene may occur in multiple myeloma (MM), which might serve as a predictor of the development of relapsed/refractory MM.

2020年6月11日 · Here we show that BIK expression in breast cancer cell lines activates caspases and induces genomic damage through caspase-activated DNase (CAD). Despite caspase activation, apoptotic cell death...

BIK is a pro-apoptotic tumor suppressor in several human tissues and its expression in cancers is prevented by chromosomal deletions encompassing the Bik locus or by epigenetic silencing. BIK appears to be a critical effector in apoptosis induced by toxins, cytokines and virus infection.

HGNC Approved Gene Symbol: BIK. The product of the BIK gene interacts with BCL2 (151430) and BCLXL (600039) and promotes cell death (summary by Chittenden et al., 1995). The BCL2 protooncogene has been shown to enhance the survival of a variety of cell types exposed to diverse cell death-inducing stimuli.

BIK has 6,720 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or …