Gene regulatory network - Wikipedia
A gene (or genetic) regulatory network (GRN) is a collection of molecular regulators that interact with each other and with other substances in the cell to govern the gene expression levels of mRNA and proteins which, in turn, determine the function of the cell.
Gene regulatory network inference in the era of single-cell
Jun 26, 2023 · The interplay between chromatin, transcription factors and genes generates complex regulatory circuits that can be represented as gene regulatory networks (GRNs). The study of GRNs is...
Gene regulatory network reconstruction: harnessing the power …
Oct 19, 2023 · Inferring gene regulatory networks (GRNs) is a fundamental challenge in biology that aims to unravel the complex relationships between genes and their regulators. Deciphering these...
基因调控网络(gene regulatory network-GRN)分析基础概念_grn …
Aug 21, 2024 · 在生物学领域，基因调控网络（Gene Regulatory Network, GRN）的研究一直是热点话题，其复杂性和动态性为科学家们提供了深入理解生物体内部运作机制的关键线索。本文将根据标题、描述以及部分提供的内容，详细解析...
Gene regulatory networks - Latest research and news - Nature
Jan 9, 2025 · A gene regulatory network is a set of genes, or parts of genes, that interact with each other to control a specific cell function. Gene regulatory networks are important in...
From time-series transcriptomics to gene regulatory networks: A …
Aug 10, 2023 · In this review, we summarize the different types of inference algorithms specifically based on time-series transcriptomics, giving an overview of the main applications of gene regulatory networks in computational biology.
Gene Regulatory Network - an overview | ScienceDirect Topics
Gene regulatory networks (GRNs, also known as transcriptional regulatory networks) are networks of causal interactions among transcription factors and downstream genes, and are usually represented with directed graphs and inferred by gene expression data.
Gene Regulatory Networks - Madame Curie Bioscience Database …
We discuss how gene regulatory networks are inferred from time series data using simple linear dynamical models. The resulting networks show features that may be universal to biological systems. The global network properties are discussed and it is seen that these inferred networks are scale free and exhibit small world properties.
GRNdb: Gene Regulatory Network database
GRNdb is a freely accessible and user-friendly database for conveniently exploring and visualizing the predicted regulatory networks formed by transcription factors (TFs) and downstream target genes (termed regulons) based on large-scale RNA-seq data as well as the known TF-target relationships for various human and mouse conditions.
scGRN: a comprehensive single-cell gene regulatory network
Jan 5, 2024 · Gene regulatory networks (GRNs) are interpretable graph models encompassing the regulatory interactions between transcription factors (TFs) and their downstream target genes. Making sense of the topology and dynamics of GRNs is fundamental to interpreting the mechanisms of disease etiology and trans …