2024年12月25日 · GFI1 (Growth Factor Independent 1 Transcriptional Repressor) is a Protein Coding gene. Diseases associated with GFI1 include Neutropenia, Nonimmune Chronic Idiopathic, Of Adults and Neutropenia, Severe Congenital, 2, Autosomal Dominant. Among its related pathways are RNA Polymerase I Promoter Opening and Nervous system development.

Gfi1 (growth factor independence 1) is a transcriptional repressor that plays a critical role in hematopoiesis and in protecting hematopoietic cells against stress-induced apoptosis. Recent research has shown that Gfi1 upregulates the expression of the nuclear protein Hemgn, which contributes to its

Results demonstrate that GFI1 acts as a tumor suppressor gene in colorectal cancer, where deficiency of Gfi1 promotes malignancy in the colon. Gfi1 plays a key role in MM tumor growth, survival, and bone destruction and contributes to bortezomib resistance.

2015年12月10日 · In addition, the Gfi1 locus is frequently found to be a proviral integration site in retrovirus-induced lymphomagenesis, and new, emerging data suggest a role of Gfi1 in human leukemia and lymphoma, underlining the role of both factors not only in normal hematopoiesis, but also in a wide spectrum of human blood diseases.

The growth factor independence-1 (Gfi1) transcription factor is required for proper development of neuroendocrine cells, sensory neurons, and blood. Patients with mutations in Gfi1 exhibit severe congenital neutropenia (SCN) or non-immune chronic ...

独立生长因子1 (growth factor independence 1，GFI1)是锌指蛋白家族中重要的转录抑制子，其主要通过与染色质修饰分子结合从而抑制靶基因转录，并与造血细胞发生、免疫细胞分化和恶性肿瘤进展密切相关。 近年来研究表明，GFI1分子在多种疾病中以不同机制发挥功能。 因此，对GFI1分子的研究将有助于理解相关疾病的发病机制，并希望对预测恶性肿瘤的靶标有所提示。 引用本文: 何香川, 邢文婧, 任欢. 独立生长因子1作用机制与相关疾病 [J] . 国际免疫学杂志, 2017, 40 (5) : …

2021年12月2日 · Growth factor indepdendent 1 (GFI1) is a SNAG-domain, DNA binding transcriptional repressor which controls myeloid differentiation through molecular mechanisms and...

该基因编码一种核锌指蛋白，可作为转录抑制因子发挥作用。 这种蛋白质在不同的发育环境中发挥作用，包括造血和肿瘤发生。 它作为复合物的一部分与其他辅助因子一起发挥作用，以控制导致靶基因启动子沉默的组蛋白修饰。 该基因的突变会导致常染色体显性遗传性严重先天性中性粒细胞减少症，以及成人显性非免疫性慢性特发性中性粒细胞减少症，这是导致白血病和感染易感性的异质性造血系统疾病。 已为该基因鉴定出编码相同蛋白质的多个选择性剪接变体。 [RefSeq 提 …

2019年3月20日 · Here we show that Gfi1b forms complexes with β-catenin, its co-factors Pontin52, CHD8, TLE3 and CtBP1 and regulates Wnt/β-catenin-dependent gene expression. In reporter assays, Gfi1b can activate...

2024年9月17日 · Hematopoietic transcription factor GFI1 promotes anchorage independence by sustaining ERK activity in cancer cells. Wang H, Lin Z, Nian Z, Zhang W, Liu W, Yan F, Xiao Z, Wang X, Zhang Z, Ma Z, Liu ZWang H, et al. J Clin Invest, 2022 Sep 1. PMID 35819844. GFI1 regulates chromatin state essential in human endothelial-to-haematopoietic transition.