2024年12月25日 · GFRA3 (GDNF Family Receptor Alpha 3) is a Protein Coding gene. Diseases associated with GFRA3 include Prostate Cancer and Breast Duct Papilloma. Among its related pathways are MAPK family signaling cascades and Nervous system development.

GDNF family receptor alpha-3 (GFRα3), also known as the artemin receptor, is a protein that in humans is encoded by the GFRA3 gene. [5][6] The protein encoded by this gene is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor and a …

2025年2月8日 · GFRa3 is expressed at the surface of a subset of Ngn3-positive endocrine progenitors as well as of embryonic alpha- and beta-cells in the mouse pancreas. cold allodynia is mediated exclusively by a single molecular pathway, suggesting that artemin-GFRalpha3 signaling can be targeted to selectively treat cold pain.

Gene ID: 2676, updated on 8-Feb-2025. The protein encoded by this gene is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor and a member of the GDNF receptor family. It forms a signaling receptor complex with RET tyrosine kinase receptor and binds the ligand, artemin. [provided by RefSeq, Jul 2008]

2024年3月5日 · The GFRA3 promoter region showed marked hypermethylation in almost all tumors, and its correlation with survival and other clinicopathological parameters may have important prognostic significance. Title: GFRA3 promoter methylation may be associated with decreased postoperative survival in gastric cancer.

该基因编码的蛋白质是糖基磷脂酰肌醇 (GPI) 连接的细胞表面受体，是 GDNF 受体家族的成员。 它与 RET 酪氨酸激酶受体形成信号受体复合物并结合配体 Artemin。 [RefSeq 提供，2008 年 7 月] The protein encoded by this gene is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor and a member of the GDNF Receptor family.

GFRA3/GDNFR-α-3 蛋白是神经胶质细胞系源性神经营养因子 的受体，可促进 artemin 诱导的自身磷酸化和 RET 受体酪氨酸激酶激活。它与 SORL1 相互作用，暗示可能参与与神经营养反应相关的信号级联反应。

GFRalpha3 is an orphan member of the GDNF/neurturin/persephin receptor family. SorLA controls neurotrophic activity by sorting of GDNF and its receptors GFRα1 and RET. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

预测能够实现轴突引导受体活性和胶质细胞衍生神经营养因子受体活性。 预测参与神经系统发育。 预测在轴突引导、神经元迁移和交感神经系统发育的上游或内部发挥作用。 预测位于细胞质和质膜外部。 预测是受体复合物的一部分。 预测在质膜的外部侧活跃。 是坐骨神经病的生物标志物。 与人类的GFRA3（GDNF家族受体α3）正链同源。 [由基因组资源联盟，2022年4月提供] Dir./Indir. Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high …

Our goal in the present study was to characterise the expression of GFRα3 in nonneuronal cells in the bone marrow. Immunohistochemical studies revealed that GFRα3-expressing cells in the bone marrow are spatially associated with blood vessels and are …