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2019年10月7日 · Several short-term studies aiming to increase GH in older adults by a variety of interventions including exercise, administration of GH, or treatment with GH secretagogues have demonstrated consistent effects to improve body composition, yet inconsistent effects on physical and cognitive function.

Role of growth hormone (GH) in mammalian aging is actively explored in clinical, epidemiological, and experimental studies. The age-related decline in GH levels is variously interpreted as a symptom of neuroendocrine aging, as one of causes of ...

Complex relationships between growth hormone (GH) signaling and mammalian aging continue to attract attention of many investigators. Recent results include evidence that the impact of GH on genome maintenance (DNA damage and repair) is drastically ...

2019年11月2日 · Recombinant human GH (rhGH) therapy administered as daily subcutaneous injections has been shown to be beneficial in the treatment of GH deficiency (GHD) in children (CGHD) and adults (AGHD). Efficacy of rhGH therapy is dependent upon making the correct diagnosis, administering the appropriate dosage of rhGH, and maintaining patient adherence ...

The interrelationships of growth hormone (GH) actions and aging are complex and incompletely understood. The very pronounced age-related decline in GH secretion together with benefits of GH therapy in individuals with congenital or adult GH deficiency (GHD) prompted interest in GH as an anti-aging a …

Growth hormone (GH) actions impact growth, metabolism, and body composition and have been associated with aging and longevity. Lack of GH results in slower growth, delayed maturation, and reduced body size and can lead to delayed aging, increased healthspan, and a remarkable extension of longevity.

Because GH/IGF-1 are master regulators of cellular function, impaired GH and IGF-1 signaling in aging/disease states leads to significant alterations in tissue structure and function, especially within the brain. This review is intended to highlight the effects of the GH and IGF-1 on neuronal structure, function, and plasticity.

2018年5月11日 · In both humans and mice, elevation of GH levels into the supranormal (pathological) range is associated with increased disease risks and reduced life expectancy likely representing acceleration...

2002年11月13日 · During 26 weeks of GH and/or sex steroid treatment, IGF-I, E 2, and testosterone levels increased into the mid-normal range for young women and men. In both sexes, GH increased LBM and decreased fat mass. Among men taking GH + testosterone, strength increased marginally and O 2 max increased significantly.