1991年7月12日 · Mutations that cause pituitary dwarfism in the mouse reside in the gene encoding the transcription factor growth hormone factor 1 (GHF1 or pit1). These dwarf mice (dw and dwJ) are deficient in growth hormone (GH) and prolactin (PRL) synthesis and exhibit pituitary hypoplasia, suggesting a stem cell defect.

Pituitary-specific expression of the growth hormone (GH) gene is governed by a transcription factor, GHF-1, that binds to two sites within its promoter. Recently, GHF-1 was shown to be a member of the homeobox family of DNA-binding proteins.

Growth hormone factor 1 (GHF-1) is a pituitary-specific transcription factor that plays a critical role in cell type-specific expression of the growth hormone (GH) gene. Here, we describe the isolation of bovine and rat GHF-1 cDNA clones.

1996年10月4日 · Using a series of site-specific mutations and deletions of the proximal rPRL promoter we have mapped the major Ras/Raf response element (RRE) to a composite Ets-1/GHF-1 binding site located between positions −217 and −190.

1988年11月4日 · Growth hormone factor 1 (GHF-1) is a pituitary-specific transcription factor that plays a critical role in cell type-specific expression of the growth hormone (GH) gene. Here, we describe the isolation of bovine and rat GHF-1 cDNA clones.

1992年6月1日 · Differential splicing of the GHF1 primary transcript gives rise to two functionally distinct homeodomain proteins. The POU domain protein GHF‐1 has a critical role in generation, proliferation and phenotypic expression of three pituitary cell types.

The GH-expressing somatotrope is derived from an acidophylic stem cell that appears during the ontogeny of the anterior pituitary which also gives rise to the prolactin (PRL)-expressing lactotrope (Chatelain et al., 1979).

1995年12月1日 · PRL and GH gene expression depend on the presence of the pituitary-specific transcription factor GHF-1/Pit-1. We have examined the effects of retinoic acid (RA) on the expression of the GHF-1/Pit-1 gene. RA induced a time- and dose-dependent increase in GHF-1/Pit-1 messenger RNA in the PRL-producing cell line 235-1.

Using a series of site-specific mutations and deletions of the proximal rPRL promoter we have mapped the major Ras/Raf response element (RRE) to a composite Ets-1/GHF-1 binding site located between positions −217 and −190.