生长激素受体 ( growth hormone receptor,GHR) 是GH发挥作用的生理基础, GH必须与靶细胞表面的GHR 结合，诱导GHR分子同源二聚化，然后激活细胞内一系列信号传导 [1]。 当体内GH水平低于或等于生理激素浓度时， GH 与GHR 以1：2 相结合。 在超生理激素浓度下,激素饱和了所有的受体分子形成1：1 的复合物,阻止了受体二聚化和信号传递。 当GH 水平增高而GHR基因表达没有增加时,不仅GH的作用不能完全发挥,而且可能因为GH过剩而产生负反馈调节,影响其他生理功 …

深入研究ISS中 GHR 候选基因的筛查、蛋白功能表达及SNP分析，有利于提高ISS的遗传诊断水平，对明确ISS的病因及指导临床治疗具有重要意义。 引用本文: 李嫔. 生长激素受体基因异常及多态性与特发性矮小的关系研究进展 [J] . 中华实用儿科临床杂志, 2014, 29 (20) : 1523-1525. DOI: 10.3760/cma.j.issn.2095-428X.2014.20.002. 版权归中华医学会所有。 未经授权，不得转载、摘编本刊文章，不得使用本刊的版式设计。 除非特别声明，本刊刊出的所有文章不代表中华医学 …

GH exerts its actions through binding with two receptor molecules at the cell surface and interaction with Janus kinase and signal transducers and activators of transcription, and other likely effectors to stimulate metabolic effects and IGF synthesis.

2025年1月21日 · This review focuses on our current understanding of how growth hormone releasing hormone (GHRH): 1) stimulates GH release and synthesis from pituitary growth hormone (GH)-producing cells (somatotropes), 2) drives somatotrope proliferation, 3) is negatively regulated by somatostatin (SST), GH and IGF1, 4) is altered throughout lifespan and in res...

2023年8月1日 · Human growth hormone (hGH) is a pituitary-derived endocrine protein that regulates several critical postnatal physiologic processes including growth, organ development, and metabolism. Following adulthood, GH is also a regulator of multiple pathologies like fibrosis, cancer, and diabetes.

Both GH and GnRH have demonstrated potent neurotrophic, neuroprotective, and neuroregenerative action. Positive behavioral and cognitive effects are also associated with GH and GnRH administration. Increasing evidence suggests the possibility of a multifactorial therapy that includes both GH and GnRH.

2006年2月1日 · Schematic representation of the 3D structure of GH complexing two molecules of growth hormone receptor (GHR). The helical segments of GH are shown in red, while the receptor molecules (GHR1 and GHR2) are colored in cyan.

In consequence, we selected acromegaly and Laron syndrome due to GH receptor deficiency (GHRD) as models for excess and absence of GH action, and focused in the role of GH/GHR signaling in the genesis of cancer and diabetes.

2011年2月1日 · The main focus of this review is on the GH-gene cluster, the GHRH-, GHRH-receptor-and finally on the GH-receptor (GHR)-gene. Further, as far as the GHR is concerned we would like to highlight the future impact of pharmocogenetics/pharmacogenomics as well as …

2018年3月16日 · In this Review, we describe the history of GH research and clinical use with a particular focus on disorders in childhood. The great complexity of the growth hormone (GH)–insulin-like growth factor...