2021年5月4日 · We present evidences that GIPC2 upregulates p27 and suppresses PPGL cell proliferation and tumor growth both in vitro and in vivo, and we propose a GIPC2-based mechanism through which sporadic...

2022年3月28日 · Functional studies demonstrated that high GIPC2 expression due to CpG-island demethylation promoted increased metastatic capabilities of PCa cells. Conversely, silencing GIPC2 expression significantly inhibited PCa metastasis in vitro and in vivo.

2024年12月25日 · GIPC2 (GIPC PDZ Domain Containing Family Member 2) is a Protein Coding gene. Diseases associated with GIPC2 include Waardenburg Syndrome, Type 4A and Pheochromocytoma. An important paralog of this gene is GIPC1.

Immunohistochemistry (IHC) GIPC2 protein detection was performed using IHC with horseradish peroxidase. The concentrated rabbit polyclonal antibody against human GIPC2 protein was purchased from BIOSS (cat no. KT22301; 1:200). Normal adult kidney tissue was used as a positive control and PBS was used as a negative control.

2021年5月4日 · By analyzing 22 sporadic PPGLs using SNP 6.0 genotyping arrays combined with expression profiling of 4 normal and 4 tumor tissues, we identified GIPC2, a gene located at 1p31.1 with preferential expression in adrenal and inducible by adrenal glucocorticoid, as a novel putative tumor suppressor gene for PPGLs.

Results: We found that GIPC2 was low expressed in colorectal cancer and highly related with the CRC clinical-stage grade and TNM stage. Furthermore, GPD1L is correlated with GIPC2 via the correlation analysis in CRC and they were associated …

Methods: The GIPC2 expression in colorectal cancer was examined by the TCGA database analysis, IHC from the human protein atlas and qRT-PCR tests. GO and KEGG enrichment analyses were performed for genes that were both correlated with the …

The GIPC2 expression in colorectal cancer was examined by the TCGA database analysis, IHC from the human protein atlas and qRT-PCR tests. GO and KEGG enrichment analyses were performed for genes that were both correlated with the expression of GIPC2 and GPD1L.

IHC-P analysis of human kidney tissue by anti-human GIPC2 antibody (BDAM0707). IHC-P was performed using sections of the formalin-fixed paraffin-embedded human kidney tissue. Antigen was retrieved through addition of boiling Tris/EDTA buffer pH 9 in a pressure cooker for 3 min. Endogenous peroxidase activity was quenched by incubating the ...

2021年5月4日 · In this study, using high-resolution microarrays and selecting for genes with preferential expression in adrenal, we identified a novel tumor suppressor gene GIPC2, that was inactivated in a majority of sporadic PPGL tumors due to copy number deletion and promoter hypermethylation.