Four GIRK genes have been identified (GIRK1-4). GIRK4 (Kir3.4) has a role in regulating energy homeostasis, since mice with a targeted mutation in the GIRK4 gene exhibit a predisposition to late-onset obesity. GIRK4 mRNA is expressed in hypothalamic regions that harbor neurons involved in the regulation of food intake and body weight.

G蛋白激活的内向整流型钾通道4（GIRK4）是G蛋白偶联内向整流型钾通道家族成员之一，由KCNJ5编码，广泛分布于哺乳动物心、脑等组织器官。 近年研究发现，GIRK4基因异常表达与心房纤颤相关，而且可能与肥胖、代谢综合征等众多其他临床疾病的发生、发展密切相关，阐明GIRK4基因在临床疾病中的病理生理机制对探讨一些临床疾病新的诊治思路具有重要的开拓性意义。 G protein-coupled inward rectifier K + channel 4 (GIRK4) is a G protein-coupled inward …

2022年6月1日 · Here, we report the first highly selective small-molecule activator targeting GIRK4 homomeric channels, 3hi2one-G4 (3- [2- (3,4-dimethoxyphenyl)-2-oxoethyl]-3-hydroxy-1- (1-naphthylmethyl)-1,3-dihydro-2H-indol-2-one). We show that 3hi2one-G4 does not activate GIRK2, GIRK1/2, or GIRK1/4 channels.

2024年6月21日 · GIRKs（G protein-coupled Inwardly Rectifying Potassium channels）是指由G蛋白偶联内向整流钾离子通道构成的离子通道家族。 它们在调节神经元和心肌细胞的电兴奋性、心率和信号传导中起重要作用。 GIRK通道通过允许钾离子流出细胞，维持细胞膜的负电位，从而抑制细胞的兴奋性。 ### 2. 结构与功能. #### 结构. GIRK通道是由四个亚基（通常是GIRK1、GIRK2、GIRK3或GIRK4）组成的四聚体，每个亚基有两个跨膜区（M1和M2）、一个胞外环和一个胞 …

2010年4月14日 · G protein-gated inwardly rectifying potassium (GIRK) channels hyperpolarize neurons in response to activation of many different G protein-coupled receptors and thus control the...

G protein-coupled inward rectifier K＋ channel 4 （GIRK4） is a G protein-coupled inward rectifier potassium channel family member. Encoded by the KCNJS, it is widely distributed in the mammalian heart, brain, and other tissues and organs.

GIRK4 brain expression patterns revealed by both labeled oligonucleotide and cRNA probes were consistent for the three wild-type mice tested. GIRK4 mRNA was restricted to only a few neuronal populations, and the overall expression pattern was primarily consistent with that described for the developing rat (Karschin and Karschin, 1997).

GIRK1 and GIRK4 subunits combine to form the heterotetrameric acetylcholine-activated potassium current (I KACh) channel in pacemaker cells of the heart. The channel is activated by direct binding of G-protein G βγ subunits. The GIRK1 subunit is atypical in the GIRK family in having a unique (∼125-amino acid) domain in its distal C terminus.

2018年1月19日 · We present functional evidence that the GIRK channel in ventricular myocytes is a GIRK1/GIRK4 heteromer, and that it mediates the impact of cholinergic signaling on APD and excitability of these...

G蛋白激活的内向整流型钾通道4 (GIRK4)是G蛋白偶联内向整流型钾通道家族成员之一,由KCNJ5编码,广泛分布于哺乳动物心、脑等组织器官。 近年研究发现,GIRK4基因异常表达与心房纤颤相关,而且可能与肥胖、代谢综合征等众多其他临床疾病的发生、发展密切相关,阐明GIRK4基因在临床疾病中的病理生理机制对探讨一些临床疾病新的诊治思路具有重要的开拓性意义。 百度学术集成海量学术资源，融合人工智能、深度学习、大数据分析等技术，为科研工作者提供全面快 …