2014年8月11日 · Our data reveal that the suppression of Hh signaling in the absence of cellular contacts is independent of primary cilia and is mediated by the YAP oncogene. …

Our findings established a novel signaling mechanism by which the interaction between Gli1 and YAP1 promotes ESCC cell growth. This signaling regulation of the tumorigenesis provides a …

2024年11月6日 · With the development of neuroscience, understanding the functions of YAP in the physiological or pathological processes of glia is advancing. In this review, we aim to …

The transcriptional coactivators yes-associated protein (Yap) and transcriptional coactivator with PDZ-binding motif (Taz) function as mechanosensors in cancer cells and have been …

2017年8月5日 · 转录共激活因子是相关蛋白（Yap）和具有PDZ结合基序的转录共激活因子（Taz）在癌细胞中起机械传感器的作用，并参与肾脏中成纤维细胞的调节。 我们假设肾纤维 …

Yap/Taz Deletion in Gli-Derived Myofibroblasts Partially Reversed UUO-Induced Kidney Fibrosis. To test whether Yap is a therapeutic target, we studied Yap f/f /Taz f/f /Gli1-ERCre mice after …

2019年5月1日 · Yes-associated Protein (YAP) is an oncogene in many cancer types, and high YAP expression was correlated with worse overall survival of RCC patients according to The …

结论: Yap/Taz信号激活促进了肾脏Gli1+肌成纤维细胞的增殖,活化,参与肾脏纤维化的发生,发展. 百度学术集成海量学术资源，融合人工智能、深度学习、大数据分析等技术，为科研工作者提供 …

2024年11月6日 · Yes-associated protein (YAP), the key transcriptional co-factor and downstream effector of the Hippo pathway, has emerged as one of the primary regulators of neural as well …

2024年11月30日 · In this review, we summarise the evidence on how YAP and TAZ are activated in epidermal keratinocytes; how YAP/TAZ-mediated signalling cooperates with other signalling …