2024年12月25日 · GLI2 (GLI Family Zinc Finger 2) is a Protein Coding gene. Diseases associated with GLI2 include Culler-Jones Syndrome and Holoprosencephaly 9. Among its related …

2025年2月19日 · Herein, we identified the Hedgehog transcription factor, GLI2, as a key node of tumor-mediated immune evasion and immunotherapy resistance during MT. GLI2 generated …

Gli proteins are transcriptional effectors of the Hedgehog signaling pathway. They play key roles in the development of many organs and tissues, and are deregulated in birth defects and cancer.

GLI family zinc finger protein 2 promotes skin fibroblast proliferation and DNA damage repair by targeting the miR-200/ataxia telangiectasia mutated axis in diabetic wound healing. TGF …

The GLI2 gene encodes one of the three zinc finger transcription factors that are involved in Hedgehog signaling. It was identified by using GLI1 cDNA as a probe (Ruppert et. al, 1988). …

The SMO-β-arrestin complex inhibits both cAMP-dependent PKA and CK1, blocking the phosphorylation and proteolytic cleavage of GLI2/3. The full-length GLI proteins are active and …

2021年12月13日 · GLI2 is 1 of 3 vertebrate transcription factors implicated as obligatory mediators of Sonic hedgehog (SHH; 600725) signal transduction. Diminished SHH signaling is …

2020年11月30日 · Heterozygous GLI2 mutations can manifest as holoprosencephaly 9 with variable expressivity and incomplete penetrance within and between families. This means that …

2025年2月8日 · GLI family zinc finger protein 2 promotes skin fibroblast proliferation and DNA damage repair by targeting the miR-200/ataxia telangiectasia mutated axis in diabetic wound …

2020年9月18日 · The Hedgehog-regulated transcription factors GLI1 and GLI2 play overlapping roles in development and disease; however, the mechanisms underlying their interplay remain …