2020年5月11日 · We highlight how classes of glioma differ in their cellular architecture and relate the observed cellular states to established GSC markers. We additionally propose a set of single-cell informed definitions as a framework for our understanding of the cellular architecture of gliomas and a potential therapeutic outlook.

2021年4月30日 · Currently, there are four major strategies for generating glioblastoma mouse models: spontaneous, transgenic, transplant, and humanized (Table 1). Major experimental glioblastoma mouse models. Spontaneous mouse glioblastoma tumors are rare (24).

2 天之前 · This study aimed to conduct a comprehensive multi-omics analysis of gliomas using various bioinformatics approaches to identify potential therapeutic targets and prognostic markers.

2025年3月12日 · Fourteen distinct glioma cellular subpopulations, seven primary cell types, and four macrophage/monocyte subtypes were identified. Developmental trajectory analysis offered insights into the origins and heterogeneity of malignant cells as well as macrophages/monocytes.

2 天之前 · Glioma is a complex disease, and prognosis can depend on clinical, genomic and radiological information. Here, the authors develop a multimodal fusion subtyping model to integrate data modalities ...

5 天之前 · Gliomas are highly malignant tumors of the central nervous system, and their complex molecular heterogeneity poses major therapeutic challenges.

2024年10月1日 · The purpose of this study is to explore the construction of biophysical cell model for the application of radiation therapy and the mechanism of biological effects in glioma cells.

2025年3月18日 · Here, we comprehensively analyzed the two major BBB cell types, endothelial and mural cells, across non-tumor brain tissue, isocitrate dehydrogenase (IDH) mutant (IDH mut) low-grade gliomas, IDH wild-type (IDH WT) high-grade glioblastomas (GBMs), and BrMs from various primary tumors.

Glioma is a rare cancer (6 diagnoses per 100,000 people annually) of the central nervous system (CNS) originating from (precursors of) glial cells [41]. The vast majority is characterized by diffuse infiltrative growth into the surrounding CNS parenchyma [29].

2024年10月1日 · Understanding the interactions between glioma cells/glioma stem cells (GSCs) and these noncancerous cells is crucial for exploring the pathogenesis and development of glioma. To invesigate these interactions requires in vitro co-culture models that closely mirror the actual TME in vivo.