2024年12月25日 · GLP2R (Glucagon Like Peptide 2 Receptor) is a Protein Coding gene. Diseases associated with GLP2R include Short Bowel Syndrome and Bowel Dysfunction. Among its related pathways are GPCR downstream signalling and Presynaptic function of …

The GLP2 receptor (GLP2R) is a G protein-coupled receptor superfamily member closely related to the glucagon receptor (GLP1 receptor). Glucagon-like peptide-2 (GLP2) is a 33-amino acid proglucagon-derived peptide produced by intestinal enteroendocrine cells.

该基因编码与胰高血糖素受体密切相关的 G 蛋白偶联受体，并与胰高血糖素样肽 2 (GLP2) 结合。 通过 GLP2 的信号刺激肠道生长并增加小肠绒毛高度，同时伴随着隐窝细胞增殖增加和肠细胞凋亡减少。 [RefSeq 提供，2014 年 12 月] This gene encodes a G protein-coupled receptor that is closely related to the Glucagon Receptor and binds to glucagon-like peptide-2 (GLP2).

2020年11月25日 · Glucagon-like peptides (GLP-1 and GLP-2) are two proglucagon-derived intestinal hormones that mediate distinct physiological functions through two related receptors (GLP-1R and GLP-2R) which...

2021年9月28日 · Here we review the current state of the literature and evaluate the identity of Glp1r, Glp2r, and Gipr expressing cells within preclinical and clinical models. Further elaboration of our understanding of the initiating G-protein coupled receptor (GPCR) circuits engaged locally within the intestine and how they become altered with high-fat diet ...

脂蛋白1r+) 和平滑肌细胞 (Glp2r+)，明确的细胞定位和共表达，特别是关于 吉普难以捉摸。在这里，我们回顾了文献的现状并评估了Glp1r, Glp2r， 和 吉普在临床前和临床模型中表达细胞。

2020年11月26日 · 胰高血糖素样肽（GLP-1和GLP-2）是两种胰高血糖素衍生的肠道激素，它们通过两个相关受体（GLP-1R和GLP-2R）介导不同的生理功能，这两个受体分别是代谢紊乱和克罗恩病的重要药物靶标。 尽管在GLP-1R结构测定方面取得了巨大进展，但对这两种受体之间的肽结合和信号转导差异的了解仍然难以捉摸。 2020年11月25日， 中国科学院上海药物研究所王明伟，徐华强及浙江大学张岩共同通讯在Cell Research 在线发表题为“A unique hormonal recognition …

GLP-2 receptors are highly expressed in gastrointestinal stromal tumors and Crohn's disease. GLP2R encodes a G protein-coupled receptor and involved in proliferative and anti-apoptotic cellular responses. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)

2014年8月1日 · Therapeutically, GLP-2 showed a weak restorative effect on intestinal inflammation during TNBS-induced colitis as assessed by macroscopic score and inflammatory markers. Finally, GLP-2 treatment accelerated mouse liver regeneration following partial hepatectomy as assessed by histological and molecular analyses.

2025年2月8日 · Glp2r and ErbB pathways as essential components of the signaling network regulating the adaptive mucosal response to refeeding in the mouse intestine. GLP-2 in the gut acts by activating receptors on the subepithelial myofibroblasts, causing the release of growth factors, which in turn stimulate intestinal growth