2024年12月25日 · GLS2 (Glutaminase 2) is a Protein Coding gene. Diseases associated with GLS2 include Metabolic Acidosis and Juvenile Dermatitis Herpetiformis. Among its related pathways are Gene expression (Transcription) and Transmission across Chemical Synapses. Gene Ontology (GO) annotations related to this gene include glutaminase activity.

GLS2 is a part of the glutaminase family. The protein encoded by this gene is a mitochondrial phosphate-activated glutaminase that catalyzes the hydrolysis of glutamine to stoichiometric amounts of glutamate and ammonia. Originally thought to be liver-specific, this protein has been found in other tissues as well.

gls2是一个p53靶基因，p53能激活gls2表达，同时降低细胞内活性氧，保护细胞基因组免受损伤。 其他抑癌基因，如Rb和LKB1，通过E2F3抑制ASCT2的表达来影响谷氨酰胺的摄取。

肿瘤细胞过度激活了肾型谷氨酰胺酶(gls)，gls2主要作用于在非癌细胞，催化谷氨酰胺的代谢。 谷氨酰胺在细胞功能中的多效性作用，如能量合成、大分子合成、mTOR活化和活性氧平衡，使得GLS抑制剂在组合治疗发挥了协同作用。

2010年4月20日 · We identified a p53 target gene, phosphate-activated mitochondrial glutaminase (GLS2), a key enzyme in conversion of glutamine to glutamate, and thereby a regulator of glutathione (GSH) synthesis and energy production. GLS2 expression is induced in response to DNA damage or oxidative stress in a p53 …

We demonstrate for the first time simultaneous expression of two transcript variants from the Gls2 gene in human, rat and mouse. A combination of RT-PCR, primer-extension analysis, bioinformatics, real-time PCR, in vitro transcription and translation and immunoblot analysis was applied to investigate GLS2 transcripts in mammalian tissues.

2024年3月1日 · gls是一种线粒体酶，分为gls1和gls2两种亚型，gls1是一种线粒体基质蛋白，在转录阶段通过不同的剪切方式又可分为gac（肝型）和kag（肾型）两种亚型，gac只存在于线粒体中，通过对肿瘤代谢物水平的调控参与肿瘤转移，而kag主要在细胞质中发挥作用，kag主要是 ...

2022年9月16日 · Glutamine synthase 2 (GLS2) is a key regulator of glutaminolysis and has been previously implicated in activities consistent with tumor suppression. Here we generated Gls2 knockout (KO) mice that develop late-occurring B-cell …

2019年10月1日 · Efforts to target glutamine metabolism for cancer therapy have focused on the glutaminase isozyme GLS. The importance of the other isozyme, GLS2, in cancer has remained unclear, and it has been described as a tumor suppressor in some contexts. Here, we report that GLS2 is upregulated and essential i …

The protein encoded by this gene is a mitochondrial phosphate-activated Glutaminase that catalyzes the hydrolysis of glutamine to stoichiometric amounts of glutamate and ammonia. Originally thought to be liver-specific, this protein has been found in Other tissues as well.