Excitatory amino acid transporter (EAAT) 1 and EAAT2 are Na + -dependant glutamate transporters expressed predominantly in glia cells of the central nervous system. As the most …

L-Glutamate (Glu) is the major excitatory neurotransmitter in the mammalian CNS and five types of high-affinity Glu transporters (EAAT1–5) have been identified. The transporters EAAT1 and …

谷氨酸转运体有高亲和力转运体,即兴奋性氨基酸转运体(excitatory amino acid transporters, EAATs)和低亲和力转运体,即囊泡谷氨酸转运体(vesicular glutamate transporters, VGLUTs)两 …

2024年11月26日 · 兴奋性氨基酸转运体（EAATs）家族通过将谷氨酸回收回神经元和星形胶质细胞，迅速从突触间隙和周围细胞外空间中移除谷氨酸，从而帮助终止谷氨酸的兴奋信号。 通过 …

EAAT1 is highly expressed in the neocortex and cerebellum, especially in astrocytes [2,19]; EAAT2 is the main glutamate transporter found in the forebrain; it is abundantly expressed in …

L-Glutamate (Glu) is the major excitatory neurotransmitter in the mammalian CNS and five types of high-affinity Glu transporters (EAAT1-5) have been identified. The transporters EAAT1 and …

Here we study the differential roles of the EAAT1, EAAT2 and EAAT5 subtypes in glutamate (GLU) uptake at the photoreceptor-to-depolarizing bipolar cell synapse in intact dark-adapted …

2017年9月21日 · Excitatory amino acid transporters (EAATs) are responsible for the reuptake of glutamate, preventing non-physiological spillover from the synapse. Postmortem studies...

2015年2月1日 · On the basis of their relative Glu transport rates and anion currents, EAATs group into two functionally distinct classes, EAAT1–3 being efficient Glu transporters with small …

The astrocytic glutamate transporters excitatory amino acid transporters 1 and 2 (EAAT1 and EAAT2) play a key role in nervous system function to maintain extracellular glutamate levels at …