Physiology, Glucocorticoids - StatPearls - NCBI Bookshelf
2023年7月17日 · Glucocorticoids are steroid hormones produced from the cortex of adrenal glands (gluco-corti-coids: glucose-cortex-steroids). Glucocorticoids have a pivotal role in the glucose, protein, and fat metabolism of the body. They originate from steroid precursors and are synthesized primarily in the zona fasciculata of the adrenal cortex.
Corticosteroids-Mechanisms of Action in Health and Disease
Progress in our understanding of glucocorticoid expression patterns have uncovered a variety of mechanisms that contribute to reduced glucocorticoid responsiveness, including increased expression of the GRβ and GRα-D isoforms, changes in GR phosphorylation and homologous down-regulation of GR.
The Biology of the Glucocorticoid Receptor: New Signaling Mechanisms …
Advances in our understanding of glucocorticoid signaling have uncovered a variety of mechanisms that contribute to reduced glucocorticoid responsiveness, including increased expression of the GRβ and GRα-D isoforms, changes in GR phosphorylation, and homologous down-regulation of the receptor.
A General Introduction to Glucocorticoid Biology - PMC
Glucocorticoids (GCs) are steroid hormones widely used for the treatment of inflammation, autoimmune diseases, and cancer. To exert their broad physiological and therapeutic effects, GCs bind to the GC receptor (GR) which belongs to the nuclear receptor superfamily of transcription factors.
Physiologic and Pharmacologic Effects of Corticosteroids
Glucocorticoids stimulate the conversion of protein to carbohydrate through gluconeogenesis and promote the storage of carbohydrate as glycogen. The increase in urinary nitrogen after an increase in glucocorticoids is the result of amino acid mobilization from protein and its subsequent breakdown as a source of carbon during gluconeogenesis.
Glucocorticoids: Molecular Mechanisms of Action | SpringerLink
2018年6月10日 · In this chapter, we provide an overview of the mechanisms regulating glucocorticoid synthesis, secretion, bioavailability, physiological effects, and their signaling via the glucocorticoid receptor (GR).
Therapeutic Mechanisms of Glucocorticoids - ScienceDirect
2018年1月1日 · We discuss five topics: (i) producing ‘better’ GCs by manipulating the equilibrium between GR monomers and homodimers; (ii) strategies to modulate cell-specific targeting and pharmacokinetics of GCs; (iii) the potential therapeutic use of anti-inflammatory molecules that are induced by GCs, rather than the GCs themselves; (iv) perspectives of co...
Molecular mechanisms of glucocorticoid action and selective ...
2007年9月15日 · Their therapeutic effects are considered to be mediated by four different mechanisms of action: the classical genomic mechanism of action caused by the cytosolic glucocorticoid receptor (cGCR); secondary non-genomic effects which are also initiated by the cGCR; membrane-bound glucocorticoid receptor (mGCR)-mediated non-genomic effects; non ...
Therapeutic glucocorticoids: mechanisms of actions in ... - Nature
2020年2月7日 · Understanding the pharmacokinetic properties and mechanisms of action of glucocorticoids could inform in the development of novel therapies with fewer adverse effects.
Corticosteroids: Mechanisms of Action in Health and Disease
This article provides an overview of the molecular mechanisms that regulate glucocorticoid actions, highlights the dynamic nature of hormone signaling, and discusses the molecular properties of the GR isoforms.
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