Gonadotropin-releasing hormone receptor is a protein that in humans is encoded by the GNRHR gene. [5] [6] This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family.

2024年12月25日 · GNRHR (Gonadotropin Releasing Hormone Receptor) is a Protein Coding gene. Diseases associated with GNRHR include Hypogonadotropic Hypogonadism 7 With Or Without Anosmia and Isolated Gonadotropin-Releasing Hormone Deficiency. Among its related pathways are GPCR downstream signalling and Class A/1 (Rhodopsin-like receptors).

该受体是七次跨膜 G 蛋白偶联受体 (GPCR) 家族的成员。 它在垂体促性腺激素细胞以及淋巴细胞、乳腺、卵巢和前列腺的表面表达。 在结合促性腺激素释放激素后，该受体与激活磷脂酰肌醇-钙第二信使系统的 G 蛋白结合。 受体的激活最终导致促性腺激素黄体生成素 (LH) 和卵泡刺激素 (FSH) 的释放。 该基因的缺陷是低促性腺激素性性腺功能减退症 (HH) 的原因。 可变剪接导致编码不同异构体的多个转录变体。 该基因在 5' 区域有超过 18 个转录起始位点，在 3' 区域有多个 …

结论 GnRH-R可能是乳腺癌潜在的治疗靶点，尤其是激素受体阴性的乳腺癌。 关键词： 促性腺激素释放激素受体（GnRH-R） 乳腺癌 组织芯片 预后. 1. Department of Breast Surgery, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200011, China; 2....

Gonadotropin-releasing hormone (GnRH) that is produced in the hypothalamic neurosecretory cells is the main regulatory hormone of the HPG axis and acts in a pulsatile manner on the gonadotrope cells of the anterior pituitary gland by binding to GnRH receptors (GnRHRs) [1, 2, 3].

c.364C>T in GNRHR is a complete loss-of-function mutation which caused idiopathic hypogonadotropic hypogonadism. GNRHR (and GNRH) are expressed in trophoblast cell populations and fallopian tube epithelium at tubal ectopic pregnancy sites. first description of a GNRHR gene mutation in three patients diagnosed with polycystic ovary syndrome.

2007年5月23日 · Isolated gonadotropin-releasing hormone (GnRH) deficiency (IGD) is characterized by inappropriately low serum concentrations of the gonadotropins LH (luteinizing hormone) and FSH (follicle-stimulating hormone) in the presence of …

促性腺激素释放激素（Gonadotropin-releasing hormone, GnRH）由下丘脑分泌，刺激或抑制垂体促性腺激素的分泌，有相当的活性潜能。 促性腺激素释放激素类似物（GnRHa）可以直接作用于肿瘤组织，引起细胞的凋亡。

2025年1月4日 · Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH).

The gonadotropin-releasing hormone receptor (GnRHR), also known as the luteinizing hormone releasing hormone receptor (LHRHR), is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family.