2024年12月25日 · GNB2 (G Protein Subunit Beta 2) is a Protein Coding gene. Diseases associated with GNB2 include Sick Sinus Syndrome 4 and Neurodevelopmental Disorder With Hypotonia And Dysmorphic Facies. Among its related pathways are ADORA2B mediated anti-inflammatory cytokines production and Thromboxane signalling through TP receptor.

Guanine nucleotide-binding protein G (I)/G (S)/G (T) subunit beta-2 is a protein that in humans is encoded by the GNB2 gene. [4][5] Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit.

异源三聚体鸟嘌呤核苷酸结合蛋白 (G 蛋白) 整合受体和效应蛋白之间的信号，由 alpha、beta 和 gamma 亚基组成。 这些亚基由相关基因家族编码。 该基因编码一个β亚基。 β 亚基是 α 亚基以及某些信号转导受体和效应器的重要调节剂。 该基因在其 5' UTR 中包含一个三核苷酸 (CCG) 重复长度多态性。 [RefSeq 提供，2008 年 7 月]

2014年12月8日 · Here we demonstrate that recurrent mutations in the Gβ proteins GNB1 and GNB2 confer cytokine-independent growth and activate canonical G protein signaling. Multiple mutations in GNB1 affect the...

2010年10月19日 · In this study, we report that guanine nucleotide binding protein-β subunit 2 (Gβ2), a member of the β-subunits of the heterotrimeric G proteins and a WD40 protein, has a crucial function for...

A GNB2 gene mutation is associated with familial sinus node and atrioventricular conduction dysfunction. GNB1 and GNB2 alterations confer transformed and resistance phenotypes across a range of human tumors and may be targetable with inhibitors of G protein signaling. MIF and GNbeta2 interacted with influenza A H1N1 virus PB1-F2 protein.

2024年9月17日 · Clinical resource with information about GNB2, Neurodevelopmental disorder with hypotonia and dysmorphic facies, Sick sinus syndrome 4, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

A de novo missense variant in GNB2 was recently reported in one individual with developmental delay/intellectual disability (DD/ID) and dysmorphism. We aim to confirm GNB2 as a neurodevelopmental disease gene, and elucidate the GNB2 -associated neurodevelopmental phenotype in a patient cohort.

2022年6月17日 · The Guanine-nucleotide binding protein 2 (GNB2) encodes for β2 subunit (Gβ2) of the G-protein complex. Keeping in view the increased demand of reliable biomarkers in cancer, the current study was planned to extensively explored GNB2 expression variation and its roles in different cancers using onlin …

2021年8月26日 · Heterotrimeric G proteins, made up of an alpha subunit (see GNAS, 139320), a beta subunit, like GNB2 (see also GNB1; 139380), and a gamma subunit (see GNG2, 606981), relay signals from cell surface receptors to internal effectors.