2024年12月25日 · GOLM1 (Golgi Membrane Protein 1) is a Protein Coding gene. Diseases associated with GOLM1 include Autoimmune Hepatitis and Liver Disease. Among its related pathways are Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) and Metabolism of proteins.

Golgi membrane protein 1 (GOLM1) also known as Golgi phosphoprotein 2 or Golgi membrane protein GP73 is a protein that in humans is encoded by the GOLM1 gene. [5][6][7] Two alternatively spliced transcript variants encoding the same …

2021年9月26日 · GOLM1，又称 GOLPH2 和 GP73，是一种高尔基跨膜蛋白，参与蛋白质货物通过高尔基体运输，在各种癌症中被广泛研究，其通过 AKT/ mTOR 途径促进癌症增殖和转移的多功能作用。 它的分泌形式已被用作肝细胞癌 (HCC) 肿瘤 发生和进展患者的血清 生物标志物。 但其在抗癌免疫中的作用尚不清楚。 免疫组化结果显示， golm1 在恶性 HCC 组织中的表达水平明显高于良性肝组织。 Kaplan Meier 生存分析显示 GOLM1 高表达 (cutoff 值 = 96.5) 的 HCC 患者 …

2025年3月3日 · Extracellular GOLM1 then stimulated ERK (extracellular signal-regulated kinase) signaling cascade by binding to its putative receptor EGFR (epidermal growth factor receptor) to promote macrophage uptake of LDL (low-density lipoprotein) and enhance the corresponding macrophage immune response.

高尔基复合体在内质网输出的蛋白质的分类和修饰中起着关键作用。 该基因编码的蛋白质是 II 型高尔基体跨膜蛋白。 它处理在粗面内质网中合成的蛋白质，并协助通过高尔基体运输蛋白质货物。 已观察到该基因的表达响应于病毒感染而上调。 已经针对该基因描述了编码相同蛋白质的可变剪接转录物变体。 [RefSeq 提供，2009 年 9 月] The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum.

2021年3月1日 · GOLM1 as a critical oncogene facilitates lung cancer cell proliferation, migration and invasion. GOLM1 has oncogenic functions affecting many signaling pathways.

2025年2月8日 · GOLM1 acts as a critical oncogene by promoting prostate cancer cell proliferation, migration and invasion, and inhibiting apoptosis. GOLM1 plays oncogenic functions mainly through activating PI3K-AKT-mTOR signaling pathway. Results showed that GOLM1 was significantly upregulated in both LUAD and LUSC tissues compared to the normal controls.

2021年11月19日 · Together, our study unveils a mechanism by which GOLM1 induces CD8 + T cells suppression through promoting PD-L1 stabilization and transporting PD-L1 into TAMs with exosome dependent. Targeting PD-L1 + TAM could be a novel strategy to enhance the efficacy of anti-PD-L1 therapy in HCC.

GOLM1 (Golm 1, NM_016548) is a resident cis -Golgi membrane protein of unknown function. The first evidence of its up-regulation was shown in the hepatocytes of patients with acute and chronic forms of hepatitis and hepatocellular cancer [15].

2021年11月19日 · In this study, GOLM1 was positively correlated with infiltrating tumor-associated macrophages (TAMs) expressed high levels of programmed death-ligand 1 (PD-L1) and CD8 + T cell suppression in HCC...