Log P： 在化合物的所有分子均以中性形式存在的 pH条件下，其在一种有机相（例如辛醇）和一种水相（例如缓冲液）中分配系数的对数即为 Log P。 Log P =Log（ [化合物有机相]/ [化合物水相]） Log D： 某一特定的pH（x）下，化合物部分以离子形式存在，部分以中性分子形式存在;此pH下的化合物在一种有机相（例如辛醇）和一种水相（例如缓冲液）中分配系数的对数即为 Log D。 Log DpHx =Log（ [化合物有机相]/ [化合物水相]） Log P值取决于中性分子在两相中的分配情况， …

2022年9月3日 · What is a good LogP value for a drug? LogP is an important component of Lipinski’s Rule of 5 recommendations which predicts the drug-likeness of a new synthetic compound. According to Lipinski’s Rule of 5, an oral drug should have a LogP value <5, ideally between 1.35-1.8 for good oral and intestinal absorption.

2024年1月6日 · LogP: A Measure of Lipophilicity LogP measures the logarithm of ration between the concentration of a compound in a non-polar solvent and in water. It is common practice to measure this using octanol (PubChem 2003) as the non-polar solvent. Mathematically LogP is defined like LogP = log [Drug] non-polar [Drug] water

ACD/Labs’ logP algorithms specifically calculate partitioning between octan-1-ol and water—the most commonly used system. In this application note, we will discuss specific applications of logP in order to offer a deeper understanding of this parameter and to demonstrate its wide-ranging impact in chemistry.

According to Lipinski’s Rule of 5, an oral drug should have a LogP value <5, ideally between 1.35-1.8 for good oral and intestinal absorption. For CNS targeting drugs (capable of crossing the blood-brain barrier) the LogP value should be around 2, while in the case of drugs developed for sub-lingual absorption the LogP value should be >5.

2018年1月9日 · clogP: Everyone is aware that logP is the logarithm of partition coefficient of a compound between n-octanol and water. i.e. log (concentration of the compound in n-octanol / concentration of compound in water).

Lipophilicity is represented by the descriptors logP (also known as Kow or Pow) and logD, and is used, for example, to help predict in-vivo permeability of active compounds in drug discovery; to anticipate the impact of insecticides, herbicides, and fertilizers on various species in agrochemicals research; to develop environmental profiles of ...

LogP is the log of the partition coefficient of a solute between octanol and water, at near infinite dilution. LogP is widely used in drug discovery and development as an indicator of potential utility of a solute as a drug.

2024年10月29日 · Unlike calculated log P, which describes lipophilicity for neutral compounds only, the calculated distribution coefficient, log D, changes with pH as its calculations account …

LogD is a distribution coefficient widely used to measure the lipophilicity of ionizable compounds, where the partition is a function of the pH. For non-ionizable compounds LogP = LogD throughout pH range, whereas for ionizable compounds LogD takes into account the partition of both ionized and non-ionized forms.