
Glucose oxidase - Wikipedia
The glucose oxidase enzyme (GOx or GOD) also known as notatin (EC number 1.1.3.4) is an oxidoreductase that catalyses the oxidation of glucose to hydrogen peroxide and D-glucono-δ-lactone. This enzyme is produced by certain species of fungi and insects and displays antibacterial activity when oxygen and glucose are present. [2]
深圳大学医学部黄鹏教授团队Adv Mater:葡萄糖氧化酶用于癌症协同治疗的最新研究进展 …
2021年2月8日 · 葡萄糖氧化酶(GOx)可以专一、高效地催化葡萄糖氧化产生葡萄糖酸和H2O2。 利用GOx选择性消耗肿瘤内的葡萄糖,从而切断肿瘤的能量供给,有望实现饥饿治疗;将GOx介导的饥饿疗法与其他治疗手段相结合,发展多模式协同治疗可以为癌症治疗提供新的解决方案和思路。 从2015年起,深圳大学黄鹏教授(点击查看介绍)团队致力于基于GOx的癌症协同治疗研究。 该团队利用空心介孔有机硅纳米颗粒装载GOx和精氨酸,首次实现了基于GOx的活体肿瘤饥饿 …
深圳大学黄鹏教授团队在葡萄糖氧化酶用于癌症协同治疗方面取得 …
2020年1月5日 · 葡萄糖氧化酶(GOx)可以专一、高效地催化葡萄糖氧化产生葡萄糖酸和过氧化氢(H2O2)。 利用GOx选择性消耗肿瘤内的葡萄糖可以切断肿瘤的能量供给,从而实现饥饿治疗;将GOx介导的饥饿疗法与其他治疗手段相结合,发展多模式协同治疗可以为癌症治疗提供新的解决方案和思路。 从2015年起,深圳大学黄鹏教授(点击查看介绍)团队致力于基于GOx的癌症协同治疗研究。 该团队利用空心介孔有机硅纳米颗粒(HMON)装载GOx和精氨酸(L-Arg), …
Recent advances in glucose oxidase-based nanocarriers for tumor ...
2023年10月1日 · Glucose oxidase (GOx) can specifically catalyze the conversion of β-d-glucose into gluconic acid and hydrogen peroxide (H2 O 2) in the presence of oxygen, making it promising for tumor starvation therapy and oxidative therapy.
Biomaterials:自制备系统可利用GOx激发的NTR放大级联反应实现 …
浙江大学胡富强教授利用葡萄糖氧化酶 (GOx)作为O2消耗剂以加重乏氧,并基于此提出了一个级联策略,即GOx诱导NTR过表达和放大NTR的催化释放效果,进而用于早期抗肿瘤治疗。
Glucose Oxidase, an Enzyme “Ferrari”: Its Structure, Function ...
Glucose oxidase (GOx) is an important oxidoreductase enzyme with many important roles in biological processes. It is considered an “ideal enzyme” and is often called an oxidase “Ferrari” because of its fast mechanism of action, high stability and ...
Recent Advances in Glucose-Oxidase-Based Nanocomposites for …
Glucose oxidase (GOx) can react with intracellular glucose and oxygen (O<sub>2</sub> ) to produce hydrogen peroxide (H<sub>2</sub> O<sub>2</sub> ) and gluconic acid, which can cut off the nutrition source of cancer cells and consequently inhibit their proliferation.
Glucose Oxidase-Instructed Multimodal Synergistic Cancer Therapy
Over the past 3 years, glucose oxidase (GOx) has aroused great research interest in the context of cancer treatment due to its inherent biocompatibility and biodegradability, and its unique catalytic properties against β-d-glucose. GOx can effectively catalyze …
医学部黄鹏教授团队在《Advanced Materials》发表研究论文
葡萄糖氧化酶(GOx)可将β-D-葡萄糖催化成葡萄糖酸和过氧化氢(H2O2),从而耗竭肿瘤细胞内的葡萄糖,起到阻断肿瘤细胞糖酵解的目的。 目前,GOx与气体疗法的联合得到了越来越多的关注,例如利用GOx和L-精氨酸之间的级联反应,实现了肿瘤饥饿疗法与NO气体的高效协同治疗。...
纳米人-黄鹏AM综述:葡萄糖氧化酶指导多模式协同肿瘤治疗
2019年3月30日 · 过去三年内,葡萄糖氧化酶 (GOx) 由于其固有的生物相容性、生物可降解性和对β-D-葡萄糖的催化活性而引起了人们巨大的研究兴趣。 尤其是在癌症治疗中,GOx能有效催化葡萄糖氧化成葡萄糖酸和过氧化氢。