Glycoprotein 130 - Wikipedia
Glycoprotein 130 (also known as gp130, IL6ST, IL6R-beta or CD130) is a transmembrane protein which is the founding member of the class of tall cytokine receptors. It forms one subunit of the …
白介素IL-6信号转导及其通路研究概述 - 知乎 - 知乎专栏
IL-6结合受体有两种，一种是特异性受体 IL-6R （80kDa I型跨膜蛋白），另一种是gp130，是IL-6家族细胞因子的所有成员的常见受体亚单位。gp130可以在所有细胞表达，但IL-6R的表达受 …
Glycoprotein 130 (gp130) | 重组蛋白 | MCE - MCE-生物活性分子 ...
gp130 抑制细胞生长和迁移，降低 IL-6 诱导的 STAT3 磷酸化，降低 IL-6 诱导的 Ki67 增加。gp130 具有抗肿瘤、抗炎和抗伤害活性。gp130/IL6ST Protein, Rat (HEK293, His) 是一种重组 …
Structural insights into the assembly of gp130 family cytokine
2023年3月17日 · The interleukin-6 (IL-6) family cytokines signal through gp130 receptor homodimerization or heterodimerization with a second signaling receptor and play crucial roles …
The Human GP130 Cytokine Receptor and Its Expression—an
2023年12月22日 · GP130 is ubiquitously expressed in all organs and virtually all cell types . GP130 is central to multiple cellular processes including immune functions, hematopoiesis, …
Gp130是什么？ - 知乎
IL-6通过结合受体复合物发挥其生物学活性，该受体由2条糖蛋白链组成：80kDa的α链（IL-6Rα）和130kDa的β链（Gp130）。 IL-6以低亲和力结合IL-6Rα，然后才识别Gp130，三者高 …
Glycoprotein Gp 130 - an overview | ScienceDirect Topics
2011年2月7日 · Gp130 is a glycosylated type I membrane protein of 130–150 kilodalton (kDa) with 6 extracellular domains, a single transmembrane domain, and a cytoplasmic domain …
Signaling conformations of the tall cytokine receptor gp130
2005年5月15日 · One example is gp130, which is a shared signal transducing receptor for a family of four-helix bundle cytokines including IL-6, viral IL-6, leukemia inhibitory factor (LIF), …
The gp130 Receptor Cytokine Family: Regulators of Adipocyte …
Gp130 cytokines are involved in the regulation of numerous biological processes, including hematopoiesis, immune response, inflammation, cardiovascular action, and neuronal survival. …
gp130: a promising drug target for cancer therapy - PubMed
As gp130 signaling mediates cancer progression, inhibition of gp130 activity offers a potential and promising approach to cancer therapy. Compared to antibodies blocking individual cytokines, …