2023年3月17日 · Glycoprotein 130 (gp130) is a signaling receptor shared by interleukin-6 (IL-6) family cytokines (or gp130 family cytokines), including IL-6, ciliary neurotrophic factor (CNTF), cardiotrophin-like cytokine factor 1 (CLCF1), leukemia inhibitory factor (LIF), oncostatin M (OSM), cardiotrophin-1 (CT-1), IL-11, IL-27, IL-35, and IL-39 (1).

2021年8月16日 · LIF signaling is mediated via the LIF receptor (LIFR) complex that is comprised of LIFR and glycoprotein 130 (gp130) [7]. LIF activates multiple signaling pathways via its interaction with...

2024年5月24日 · The LIFR complex, which consists of LIFR and glycoprotein 130 (gp130), transmits LIF signals 7 through the downstream pathways including JAK/STAT3 as the immediate effectors and concurrent MAPK...

2008年9月5日 · Here, we biophysically and structurally characterize the full-length, transmembrane form of a quaternary cytokine receptor complex consisting of gp130, LIF-R, the cytokine Ciliary Neurotrophic Factor (CNTF), and its alpha receptor (CNTF-Rα).

2003年9月23日 · The cytokines LIF and OSM do not require binding to nonsignaling α receptors; they engage the signaling receptor subunits directly. LIF uses a heterodimer of gp130 and LIFR to transduce signals, and OSM uses a heterodimer of gp130 and OSMR .

2023年12月22日 · IL-6Rα and IL-11Rα signaling is strictly dependent on GP130 for STAT activation. By contrast, GP130 bound with other IL-6 cytokine family receptors, including the signaling-competent OSM receptor (OSMR), LIF receptor (LIFR) form complexes consisting of a receptor heterodimer containing a single GP130 with their respective cytokines [19,20,21 ...

2005年11月1日 · Here we investigated gp130 homodimerization and heterodimerization with the LIFR by fluorescence resonance energy transfer (FRET) and bimolecular fluorescence complementation (BiFC). We detected a FRET signal between YFP- and CFP-tagged gp130 at the plasma membrane of unstimulated cells that does not increase upon IL-6 stimulation.

2022年7月1日 · Leukemia inhibitory factor (LIF) is the most pleiotropic member of the interleukin-6 family of cytokines. 1 LIF mediates its signaling using membrane receptor complex that is comprised of LIFR and glycoprotein 130 (gp130). 2 LIF first binds to LIFR which leads to the formation of high affinity functional complex with gp130. The LIFR does not ...

2005年11月1日 · Interleukin-6 (IL-6) signals through gp130 homodimers whereas leukaemia inhibitory factor (LIF) exerts its action through a heterodimer of gp130 and the LIF receptor (LIFR). Related haematopoietic receptors such as the erythropoietin receptor have been described as preformed dimers in the plasma membrane.

Leukemia inhibitory factor (LIF), a member of the gp130 family of helical cytokines, is involved in the hemopoietic and neural systems. The LIF signal transducing complex contains two receptor molecules, the LIF receptor (LIFR) and gp130. The extracellular region of the LIFR is …