抑瘤素M (OSM): 白介素IL-6细胞因子家族成员，肿瘤、骨代谢、慢 …
Ⅱ型osm受体（gp130/osmrβ）是由一个gp130分子和一个osm受体β亚单位构成的异源二聚体，Ⅱ型受体具有osm特异性，不能结合lif及家族中的其他细胞因子（图2） [8]。
GP130/OSMR is the only LIF/IL-6 family receptor complex to …
Using a dominant-negative LIF mutant (hLIF-05), we showed that in RC cell cultures mouse OSM (mOSM) activates exclusively glycoprotein 130 (gp130)/OSMR. In treatments starting at early …
Structures of complete extracellular assemblies of type I and type …
2024年11月12日 · While type I OSM receptor complex is formed by glycoprotein 130 (gp130) heterodimerization with Leukemia Inhibitory Factor receptor (LIFR), type II OSM receptor …
Structures of the interleukin 11 signalling complex reveal gp130 ...
2023年11月20日 · Our results reveal the structural basis of IL-11 signalling, define the molecular mechanisms of an inhibitor, and advance understanding of gp130-containing receptor …
A Unique Loop Structure in Oncostatin M Determines Binding …
OSM is unique in this family as it can signal using heterodimers of gp130 with either leukemia inhibitory factor receptor (LIFR) (type I) or oncostatin M receptor (OSMR) (type II). We have …
The Cytokine Receptor gp130: Faithfully Promiscuous | Science's …
2003年9月23日 · All IL-6-type cytokine receptors that mediate signaling (gp130, LIFR, and OSMR) contain these three membrane-proximal domains, suggesting a similar overall …
OSM/OSMR and Interleukin 6 Family Cytokines in Physiological …
Oncostatin M (OSM) is a member of the interleukin-6 (IL-6) family of cytokines and can bind two different receptors, Leukemia inhibitory factor receptor (LIFR) and Oncostatin M receptor …
The Human GP130 Cytokine Receptor and Its Expression—an
2023年12月22日 · IL-6Rα and IL-11Rα signaling is strictly dependent on GP130 for STAT activation. By contrast, GP130 bound with other IL-6 cytokine family receptors, including the …
Circulation：OSM受体gp130参与调控心肌细胞增殖和心脏再生
2020年7月1日 · OSM受体异二聚体（OSMR和gp130）心肌细胞特异性缺陷时，均可减少新生鼠的心肌细胞增殖和心脏再生。 条件性激活心肌细胞的gp130可促进幼年和成年鼠的心肌细胞增殖 …
GP130/OSMR is the only LIF/IL‐6 family receptor complex to …
2005年3月4日 · Leukemia inhibitory factor (LIF) and its receptor (LIFR) are “twins” of Oncostatin M (OSM) and OSMR, respectively, likely having arisen through gene duplications. We …