Ⅱ型osm受体（gp130/osmrβ）是由一个gp130分子和一个osm受体β亚单位构成的异源二聚体，Ⅱ型受体具有osm特异性，不能结合lif及家族中的其他细胞因子（图2） [8]。

Using a dominant-negative LIF mutant (hLIF-05), we showed that in RC cell cultures mouse OSM (mOSM) activates exclusively glycoprotein 130 (gp130)/OSMR. In treatments starting at early nodule formation stage, LIF, mOSM, IL-11, and IL-6 + sIL-6R inhibit bone nodule formation, that is, osteoprogenitor differentiation.

2024年11月12日 · While type I OSM receptor complex is formed by glycoprotein 130 (gp130) heterodimerization with Leukemia Inhibitory Factor receptor (LIFR), type II OSM receptor complex is composed of gp130 and...

2023年11月20日 · Our results reveal the structural basis of IL-11 signalling, define the molecular mechanisms of an inhibitor, and advance understanding of gp130-containing receptor complexes, with potential ...

OSM is unique in this family as it can signal using heterodimers of gp130 with either leukemia inhibitory factor receptor (LIFR) (type I) or oncostatin M receptor (OSMR) (type II). We have identified a unique helical loop on OSM between its B and C helices that is not found on other IL-6 family cytokines.

2003年9月23日 · All IL-6-type cytokine receptors that mediate signaling (gp130, LIFR, and OSMR) contain these three membrane-proximal domains, suggesting a similar overall architecture of the different receptor complexes.

Oncostatin M (OSM) is a member of the interleukin-6 (IL-6) family of cytokines and can bind two different receptors, Leukemia inhibitory factor receptor (LIFR) and Oncostatin M receptor (OSMR), through a complex containing the common glycoprotein 130 (gp130) subunit.

2023年12月22日 · IL-6Rα and IL-11Rα signaling is strictly dependent on GP130 for STAT activation. By contrast, GP130 bound with other IL-6 cytokine family receptors, including the signaling-competent OSM receptor (OSMR), LIF receptor (LIFR) form complexes consisting of a receptor heterodimer containing a single GP130 with their respective cytokines [19,20,21 ...

2020年7月1日 · OSM受体异二聚体（OSMR和gp130）心肌细胞特异性缺陷时，均可减少新生鼠的心肌细胞增殖和心脏再生。 条件性激活心肌细胞的gp130可促进幼年和成年鼠的心肌细胞增殖和心脏再生。

2005年3月4日 · Leukemia inhibitory factor (LIF) and its receptor (LIFR) are “twins” of Oncostatin M (OSM) and OSMR, respectively, likely having arisen through gene duplications. We compared their effects in a bone nodule-forming model of in vitro …