本文试图讲清楚HIV是如何感染细胞的，结果不小心把细胞结构也顺带介绍了一遍。 入侵细胞gp120 (SU)与gp41 (TM)这两种病毒蛋白，它们分别可以三聚成复合物，然后通过非共价键（而不是肽键。 ）结合成复合体（异源的六…

gp120和gp41是病毒包膜中的两种糖蛋白，两种糖蛋白共同组成gp160。 当HIV进入体内跟T细胞相遇后，病毒“钩子”中的gp120蛋白会和细胞表面的 CD4蛋白 发生特异性的结合形成gp120和CD4的复合物。 HIV除了可以感染T细胞外还可以感染其他表达CD4的细胞，例如：巨噬细胞、 抗原呈递细胞 等。 gp120和CD4结合后会导致gp120的蛋白结构发生构型改变，改变后的构型成为病毒包膜表面的共受体结合位点。 共受体为T细胞表面除了CD4外辅助HIV结合的受体，通常情况下为 …

Here we determine the crystal structure of an HIV-1 gp120 core with intact gp41-interactive region in its CD4-bound state, compare this structure to unliganded and antibody-bound forms to identify structurally invariant and plastic components, and use ligand-oriented cryoelectron tomograms to define component mobility in the viral spike context.

跨膜亚基gp41与gp120发生解离,完成天然构象向膜融合活性构象的转变,从而介导了病毒与细胞膜的融合。 由于gp41比gp120要保守得多,而且还没有糖基化的问题,所以gp41已成为开发抑制HIV-1感染药物的热点。

2024年3月25日 · 近日，南方医科大学刘叔文教授团队在Cellular & Molecular Immunology杂志上发表一篇题为gp120-derived amyloidogenic peptides form amyloid fibrils that increase HIV-1 infectivity（gp120衍生的淀粉样多肽形成淀粉纤维并促进病毒感染）的研究论文。

2018年12月12日 · Here we report a cryo-electron microscopy structure of a full-length gp120 in complex with soluble CD4 and unmodified human CCR5, at 3.9 Å resolution. The V3 loop of gp120 inserts into the...

The Env glycoprotein complex projects from the virion surface as highly glycosylated spikes, composed of a heterotrimer of the surface (SU) glycoprotein gp120 and the transmembrane (TM) glycoprotein gp41. The entry process is initiated by the binding of gp120 to CD4, the primary attachment receptor for primate lentiviruses.

The gp120 molecule of HIV-1 is a glycoprotein that is part of the outer layer of the virus. It presents itself as viral membrane spikes consisting of 3 molecules of gp120 linked together and anchored to the membrane by gp41 protein. Gp120 is essential for viral infection as it …

1997年4月18日 · The envelope glycoprotein of human immunodeficiency virus type 1 (HIV-1) consists of a complex of gp120 and gp41. gp120 determines viral tropism by binding to target-cell receptors, while gp41 mediates fusion between viral and cellular membranes.

As gp120 and gp41 are attractive targets, the development of entry inhibitors represents an important avenue of anti-HIV drug therapy. The present review will focus on some general considerations about HIV, the main characteristics of gp120, gp41 and their inhibitors, with special emphasis on the advances of computational approaches employed in ...