Introduction: GPFA is an electroencephalographic (EEG) finding in patients with symptomatic generalized epilepsy consisting of 15-25Hz bifrontally predominant generalized fast activity seen predominantly in sleep. Historically GPFA is linked to epileptic encephalopathy with drug resistant epilepsy and intellectual disability.

2017年4月18日 · GPFA is an electroencephalographic (EEG) finding in patients with GGE consisting of 10–35 Hz bifrontally predominant generalized fast activity seen almost exclusively in sleep. Historically GPFA is linked to epileptic encephalopathy with tonic-absence seizures, refractory absence epilepsy and mental retardation.

2017年11月1日 · GPFA is an electroencephalographic (EEG) finding in patients with symptomatic generalized epilepsy consisting of 15-25 Hz bifrontally predominant generalized fast activity seen predominantly in sleep. Historically GPFA is linked to epileptic encephalopathy with drug resistant epilepsy and intellectual disability.

2024年11月1日 · In our study, 38.3% of EEM patients had GPFA on EEG. GPFA is an EEG pattern in individuals with EEM that can cause eyelid myoclonia. EEM patients with GPFA on their EEG had easier seizure control than those without GPFA. This study summarized the incidence and electroclinical features of GPFA in a cohort of patients with EEM. 1. Introduction.

2004年6月1日 · Sleep-EEG at age 18 revealed GPFA—frequent 3–4 secundum duration runs of 10–15 Hz activity with bifrontal amplitude-dominance—in NREM sleep (Fig. 2B)—and 3 Hz spike-wave paroxysms in drowsiness (Fig. 2A). Video-EEG monitoring revealed frequent absences with arrest of reading and movements.

Purpose: Generalised paroxysmal fast activity (GPFA) consists of 8-26 (most frequently around 10 Hz), 2-50 seconds (usually below 10 seconds) bursts of generalised rhythmic discharges with frontal predominance, appearing most frequently during NREM sleep. The pattern is traditionally linked to Lennox-Gastaut (LGS) or late LGS (LLGS) syndrome ...

Introduction: Generalized paroxysmal fast activity (GPFA) is a rare and underreported EEG pattern known to be related to epileptic encephalopathy. We aimed to investigate the electroclinical spectrum of GPFA along with other atypical EEG features in patients without epileptic encephalopathy in routine EEG practice.

Generalized paroxysmal fast activity (GPFA), historically described by various names including paroxysmal fast rhythms, 5 grand mal discharge 6 and repetitive fast discharges, 7 is a characteristic interictal epileptiform discharge seen on the electroencephalogram (EEG) in LGS, and occasionally that of patients with other developmental and ...

Here, we measured generalized paroxysmal fast activity (GPFA), a key interictal electrographic feature of LGS, and correlated GPFA burden with seizure diaries during a thalamic deep brain stimulation (DBS) treatment trial (Electrical Stimulation of the Thalamus in Epilepsy of Lennox-Gastaut Phenotype [ESTEL]).

We report seven patients with genetic generalized epilepsy (GGE) (previously known as idiopathic generalized epilepsy) with GPFA re-corded on EEG.