2024年12月25日 · GPHA2 (Glycoprotein Hormone Subunit Alpha 2) is a Protein Coding gene. Diseases associated with GPHA2 include Salt And Pepper Syndrome and Norrie Disease. Among its related pathways are GPCR downstream signalling and Class A/1 (Rhodopsin-like receptors). Gene Ontology (GO) annotations related to this gene include hormone activity.

Glycoprotein hormone alpha-2 is a protein that in humans is encoded by the GPHA2 gene. [5] [6] GPHA2 is a cystine knot-forming polypeptide and a subunit of the dimeric glycoprotein hormone family (Hsu et al., 2002). (Supplied by OMIM.) [6]

In this study, we hypothesized that glycoprotein hormone subunit A2 (GPHA2), a corneal stem cell factor and ligand for the thyroid stimulating hormone receptor (TSHR), is downstream of NOTCH2 signaling. We found Gpha2 is expressed in quiescent pituitary stem cells by RNAscope in situ hybridization and scRNA seq.

2024年3月5日 · Gene target information for GPHA2 - glycoprotein hormone subunit alpha 2 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

GPHA2 是一种胱氨酸结形成多肽和二聚糖蛋白激素家族的一个亚基 (Hsu 等人，2002 [PubMed 12089349]) 。 [OMIM 提供，2008 年 3 月] GPHA2 is a cystine knot-forming polypeptide and a subunit of the dimeric glycoprotein hormone family (Hsu et al., 2002 [PubMed 12089349]). [supplied by OMIM, Mar 2008]

2025年2月8日 · Glycoprotein hormone subunit alpha 2 (GPHA2): A pituitary stem cell-expressed gene associated with NOTCH2 signaling. expressed in osteoblasts and osteoclasts; Dual site-disrupted GPA2 and the GPB5 mutant were not expressed in …

GPHA2 is a cystine knot-forming polypeptide and a subunit of the dimeric glycoprotein hormone family (Hsu et al., 2002).[supplied by OMIM, Mar 2008]... show less

2024年5月15日 · In this study, we hypothesized that glycoprotein hormone subunit A2 (GPHA2), a corneal stem cell factor and ligand for the thyroid stimulating hormone receptor (TSHR), is downstream of NOTCH2 signaling. We found Gpha2 is expressed in quiescent pituitary stem cells by RNAscope in situ hybridization and scRNA seq.

GPHA2的详细信息，包括基因名称，代码，染色体位置，相互作用关系和通路，简述为GPHA2是胱氨酸结形成多肽和二聚体糖蛋白激素家族中的一子单元（Hsu等人，2002 [搜索PubMed 12089349]。

By searching for genes similar to glycoprotein hormone subunits, followed by EST database analysis and PCR of human ovary and testis cDNA, Hsu et al. (2002) cloned GPHA2, which they designated GPA2. The deduced 129-amino acid precursor protein contains a 23-amino acid signal peptide at its N terminus.