2024年12月25日 · Complete information for GPR160 gene (Protein Coding), G Protein-Coupled Receptor 160, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium

2020年1月30日 · Using unbiased receptomics, transcriptomic analyses, immunofluorescence, and in situ hybridization, we found that the expression of the orphan GPCR Gpr160 and GPR160 increased in the rodent dorsal horn of the spinal cord following traumatic nerve injury.

2020年5月1日 · Our findings de-orphanize GPR160, identify it as a determinant of neuropathic pain and potential therapeutic target, and provide insights into its signaling pathways.

2021年6月25日 · Higher expression of GPR160 in cancerous human prostate tissues and relationship between GPR160 expression levels and clinical characteristics of enrolled patients.

2016年3月15日 · This study investigates potential roles of GPR160, an orphan GPCR, in the pathogenesis of prostate cancer. The transcription levels of GPR160 in the prostate cancer tissue samples and cell lines, such as PC-3, LNCaP, DU145 and 22Rv1 cells, were significantly higher than that seen in normal prostate tissue and cells.

GPR160 is an orphan class A GPCR previously annotated as GPCR1 or GPCR150. The human GPR160 protein is of 338-amino acid long and encoded by 7 exons located at 3q26.2-q27 [10]. Orthologues of GPR160 have been identified in the Rhesus monkey, dog, cow, rat, mouse, chicken, zebrafish, and frog.

2024年6月1日 · Our work identified the G-protein-coupled receptor 160 (GPR160) as a potential target for therapeutic intervention. However, the lack of small-molecule ligands for GPR160 hampers our understanding of its role in health and disease.

2024年10月24日 · Increased H3K27ac levels upon tumor infiltration enhance Sp1-mediated expression of the Gpr160 in dorsal root ganglia, which contributes to bone cancer pain.

In this study, we explored the relationship between GPR160 expression and the clinical status of prostate cancer. Both mRNA and protein levels of GPR160 were correlated with age, PSA, prostate...

2025年1月4日 · Title: G protein-coupled receptor GPR160 is associated with apoptosis and cell cycle arrest of prostate cancer cells. these findings suggest an important role of GPR160 in regulating the entry of BCG into macrophages by targeting the ERK signaling pathway.