GPR75 RECEPTOR MEDIATES 20-HETE-SIGNALING AND …
GPR75 receptor antagonism significantly reduced 20-HETE-induced cell migration (% wound closure: 20-HETE, 48.9±2.7%, p<0.0001 vs. control; 20-HETE+AAA, 36.0±2.9, p<0.05 vs. 20 …
20-HETE/GPR75 pairing modulates the expression and …
2023年1月1日 · 20-HETE/GPR75 induces nuclear localization of the androgen receptor in LNCaP cells. It also increases the androgen receptor (AR) expression and transcriptional activity. …
Structure-Function Relationship of the 20-HETE-GPR75 pairing ...
2022年5月13日 · 20-Hydroxyeicosatetraenoic acid (20-HETE) and its receptor (20HR), GPR75 (Gq), exhibit diverse bioactions that promote the activation of pro-hypertensive, -diabetic and …
20-HETE-GPR75 配对的结构-功能关系：激动剂、部分激动剂和受 …
20-羟基二十碳四烯酸 (20-HETE) 及其受体 (20HR) GPR75 (Gq) 具有多种生物作用，可促进促高血压、糖尿病和肥胖信号的激活。 与靶向 GPR75 的类似物相关的药理特性仍不清楚。
20-HETE Signals Through G-Protein-Coupled Receptor GPR75 (G
2017年5月26日 · GPR75 knockdown in a mouse model of 20-HETE-dependent hypertension prevented blood pressure elevation and 20-HETE-mediated increases in angiotensin …
Uncovering the signalling, structure and function of the 20-HETE-GPR75 …
Key results: SPR confirmed 20-HETE binding to GPR75 with an estimated K D of 1.56 × 10 -10 M. In GPR75-transfected HTLA cells, 20-HETE stimulated intracellular Ca 2+ levels, IP-1 …
Activation of GPR75 Signaling Pathway Contributes to the
2022年8月1日 · This study tested the hypothesis that the GPR75 signaling pathway mediates these effects of 5,14-HEDGE in response to systemic exposure to LPS. Mean arterial pressure …
GPR75 Identified as the First 20-HETE Receptor | Circulation …
2017年5月26日 · They demonstrated that activation of GPR75 by 20-HETE in human endothelial cells promotes dissociation of the Gα q/11 subunit and release of c-Src from G1T1 (GPCR …
GPR75 receptor mediates 20-HETE-signaling and ... - ScienceDirect
2020年2月1日 · To elucidate the role of 20-HETE/GPR75 on cell invasiveness, the effect of 20-HETE on transwell invasion was analyzed on wild type PC-3 cells treated with 19-HEDE, and …
Uncovering the signaling, structure and function of the 20‐HETE‐GPR75 …
2021年5月11日 · Key results: SPR confirmed 20-HETE binding to GPR75 with an estimated KD of 1.56x10-10 M. In GPR75-transfected HTLA cells, 20-HETE stimulates intracellular Ca2+ …