2022年6月16日 · ScRNA sequencing identified GPR87 as a novel marker of basal cells in IPF, enriched in honeycomb cysts. GPR87 overexpression resulted in aberrant airway cell …

2024年10月11日 · GPR87 is highly expressed in IPF lungs, mostly in airway basal and aberrant basaloid cells, and to a certain degree, in secretory cells (Figure 1D-K), but not in immune or …

GPR87 - a G-Coupled Protein Receptor Overexpressed in Human and Murine Pulmonary Fibrosis, Localizes to Aberrant Basaloid Cells in the IPF Lung

Here, we report G-protein coupled receptor (GPR) 87 as a marker of distal bronchioles and KRT5 + basal-like cells in IPF. We generated single cell transcriptomes from EpCAM + cells isolated …

Using single-cell RNA sequencing of enriched EpCAM + lung cells of the distal IPF lung, we identified G-protein coupled receptor (GPR) 87 as a marker of distal bronchioles and KRT5 + …

G-coupled protein 87 (GPR87) is a lysophosphatidic acid (LPA) receptor expressed in airway-basal, and aberrant basaloid cells in IPF. Here we aim to assess the role of GPR87 in lung …

Conclusion: In iPSC derived basal cells GPR87 mediates LPA induction of genes known to be expressed in pulmonary fibrosis. Knock down of GPR87 leads to downregulation of fibrosis …

2024年10月13日 · GPR87 knockdown is protective against fibrosis development in normal PCLS treated with fibrotic cocktail and leads to fibrosis regression in IPF PCLS. In iBC, GPR87 …

2024年10月10日 · G- protein coupled receptor 87 (GPR87), an alternative lysophosphatidic acid (LPA) receptor previously implicated in cancer, is highly expressed in basal and aberrant …

2021年9月3日 · We identified G-protein coupled receptor (GPR) 87 as a novel surface marker of distal Keratin (KRT)5 + basal cells. GPR87 expression was localized to distal bronchioles and …