2017年3月14日 · Finally, we demonstrated that GPR87 enhanced pancreatic cancer aggressiveness by activating NF-κB signaling pathway. Conclusions: Taken together, these findings suggest that GPR87 plays a critical oncogenic role in pancreatic cancer progression and highlight its potential as a target for pancreatic cancer therapy.

To explore whether GPR87 mediates pancreatic cancer progression through NF-κB activation, luciferase reporter analysis was performed. Our results showed that the stimulatory effect of GPR87 on NF-κB activation was significantly inhibited by transfection of an IκBα dominant-negative mutant (IκBα-mut) or treatment with an NF-κB inhibitor.

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2024年12月6日 · The molecular mechanisms under such an enhanced aggressiveness of pancreatic cancer cells upon upregulation of GPR87 were shown to involve the activation of nuclear factor-κB (NF-κB) signaling, as the blockage of this pathway led to a significant suppression of GPR87-induced malignant phenotype, including increased proliferation, angiogenesis ...

研究目的: 胰腺癌是一种高度致死性以及在恶性肿瘤中预后极差的疾病,据报道,GPR87在多种肿瘤中高表达,然而,GPR87在胰腺癌中的临床意义以及生物学特点仍有待研究.

2010年4月1日 · Two additional receptors, GPR87 and P2Y5, have been proposed to be new LPA receptors [13], [14], however, further validation of these identities is required. This review will focus on the receptor-mediated signaling characteristics of LPA and its potential involvement in human diseases.

Overexpression of G protein-coupled receptor GPR87 promotes pancreatic cancer aggressiveness and activates NF-κB signaling pathway.

结果·生信分析和临床样本的数据显示，gpr87 mrna和蛋白在nsclc中高表达，且会导致患者临床分期更差、更易发生淋巴结转移，提示gpr87可能是nsclc高侵袭性的关键基因。

The effect of GPR87 on NF-κB signaling pathway was further investigated using the luciferase reporter assays, and by detection of the NF-κB signaling downstream genes. Results: Herein, we reported that GPR87 was markedly overexpressed in pancreatic cancer cells and clinical tissues.

2024年12月25日 · GPR87 (G Protein-Coupled Receptor 87) is a Protein Coding gene. Diseases associated with GPR87 include Squamous Cell Carcinoma and Lung Squamous Cell Carcinoma. Among its related pathways are Class A/1 (Rhodopsin-like …