2024年12月25日 · GPRIN1 (G Protein Regulated Inducer Of Neurite Outgrowth 1) is a Protein Coding gene. Diseases associated with GPRIN1 include Cerebral Creatine Deficiency Syndrome 2 and Xanthogranulomatous Cholecystitis. Among its related pathways are Gene expression (Transcription) and Transcriptional Regulation by MECP2.

2025年1月4日 · Gene target information for GPRIN1 - G protein regulated inducer of neurite outgrowth 1 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

2018年3月30日 · In adult neurons, GPRIN1 is highly localized to the plasma membrane and synapses where it regulates neuronal signal transduction and Ca 2+ homeostasis. Our results reveal that GPRIN1 might be a novel protein involved in agonist-stimulated cytoskeletal reorganization, which is crucial for early neuronal network development and in functionally ...

This gene has 1 transcript (splice variant) and 130 orthologues. Biased expression in brain (RPKM 11.5), duodenum (RPKM 2.2) and 5 other tissues. 预测启用磷蛋白结合活性。 预计参与神经元投射发育。 预计位于生长锥内。 预计在质膜上有活性。 [由基因组资源联盟提供，2022 年 4 月] Predicted to enable phosphoprotein binding activity. Predicted to be involved in neuron projection development.

To detect the functional effects of knockdown/overexpression of GPRIN1 on lung cancer cells, we performed CCK-8, colony formation and Transwell assays. Through the Kaplan-Meier method, we found that GPRIN1 expression correlated with overall survival and adverse prognosis, and Cox regression indicated that GPRIN1 is as an independent predictive ...

2025年2月8日 · G protein-regulated inducer of neurite outgrowth 1. A novel lncRNA-miRNA-mRNA competing endogenous RNA regulatory network in lung adenocarcinoma and kidney renal papillary cell carcinoma. Predicted to enable phosphoprotein binding activity. Predicted to be involved in neuron projection development. Predicted to be located in growth cone.

Gprin1 is a membrane anchored signaling protein that localizes to regions where cytoskeletal remodeling demands are high. In neural cells, Gprin1 can direct the formation of neurites by regulating the function of CDC42 in the growth cone (Nakata and Kozasa 2005).

2025年2月8日 · G protein-regulated inducer of neurite outgrowth 1. Enables phosphoprotein binding activity. Acts upstream of or within neuron projection development. Located in plasma membrane. Is expressed in several structures, including axial skeleton; bone; central nervous system; peripheral nervous system ganglion; and sensory organ.

Genetic inactivation of the Fanconi anemia gene FANCC identified in the hepatocellular carcinoma cell line HuH-7 confers sensitivity towards DNA-interstrand crosslinking agents. Spontaneous functional correction of homozygous fanconi anaemia alleles reveals novel mechanistic basis for reverse mosaicism.

GPRIN1调控肿瘤细胞免疫微环境、影响肿瘤耐药等作用已经成为新型抗肿瘤治疗靶点的研究热点。 本文将近年来GPRIN1在神经元突触发生和调节中的作用及GPRIN1调节恶性肿瘤发生发展方面的相关研究作一综述。