2022年7月21日 · Gustatory Receptor 64 (Gr64) genes are a cluster of 6 neuronally expressed receptors involved in sweet taste sensation in Drosophila melanogaster. Gr64s modulate calcium signalling and excitatory responses to several different sugars.

2015年3月2日 · Here, labellar sweet neurons of ΔGr64 mutant flies (lacking all six Gr64 genes) lost all spiking activity when stimulated with this sugar, similar to ΔGr5a mutants. This phenotype was rescued by overexpression of Gr64f, but not Gr64e or Gr64d. Our PER analysis supports a role for Gr64f in trehalose sensing, when elicited from tarsi.

2008年11月25日 · The results with the Gr64f siRNA suggested that Gr64f might be the receptor that is required together with Gr5a to detect trehalose. This possibility was supported by a recent in situ hybridization study demonstrating extensive coexpression of Gr64f and Gr5a RNAs [4].

2022年12月19日 · To determine whether this local Hh source regulates sweet taste perception, we used Gr64f-Gal4 to express Hh-IR in mature sweet sensory neurons 38.

2025年2月20日 · One of the few identified sugar gustatory receptors identified so far and which promotes the starvation-induced increase of feeding motivation. Required in combination with Gr64a to detect sucrose, maltose, and glucose. (UniProt, …

(A) Expression of GFP in Gr64fGAL4 neurons reveals axon terminals in the sub-esophagael zone (SEZ). Scale bar = 50 μm. (B) Diagram of live-imaging experimental protocol. Cuticle above the SEZ is...

2022年3月28日 · Together, our studies have identified GR5a, GR61a, and Gr64f as novel sensors in the fly labellum, which allow for the detection of attractive amino acids in sweet-sensing GRNs. Furthermore, IR25a and IR76b also mediate the perception of …

2017年11月9日 · Previously, we showed that a broad population of sugar-sensing taste neurons expressing Gustatory Receptor 64f (Gr64f) is required for reflexive feeding responses to both FAs and sugars. Here, we report a genetic silencing screen to identify specific populations of taste neurons that mediate fatty acid (FA) taste.

Thus, the Gr64f- transgene provides a reliable tool to evaluate co-expres-GAL4 sion with the remaining Gr64LEXA alleles in sweet GRNs of the main taste organs (Figures 1B and S1).

2017年12月12日 · Behavioral studies have established that Drosophila appetitive taste responses towards fatty acids are mediated by sweet sensing Gustatory Receptor Neurons (GRNs). Here we show that sweet GRN activation requires the function of the Ionotropic Receptor genes IR25a, IR76b and IR56d.