Granzyme B also cleaves many of the proteins responsible for apoptosis in the absence of caspase activity. The other granzymes activate cell death by caspase-dependent and caspase-independent mechanisms. [1] In addition to killing their target cells, granzymes can target and kill intracellular pathogens.

2023年3月19日 · 颗粒酶(granzyme,Gra)是细胞毒性T淋巴细胞(CTL)和自然杀伤(NK)细胞颗粒中丝氨酸蛋白酶家族的总称。 已发现的颗粒酶有A、B、C三种,其中颗粒酶B (granzyme B,Gra B)是主要的效应分子,它可以进人靶细胞,激活caspase级…

颗粒酶（英語： Granzymes ）是由杀伤性T细胞和自然杀伤细胞（NK细胞）细胞质颗粒释放出的丝氨酸蛋白酶。 颗粒酶诱导靶细胞的细胞程序性死亡（凋亡），借此可以清除癌细胞以及被病毒或细菌感染的细胞 [1] 。 颗粒酶亦可杀灭细菌 [2] 和防止病毒复制。 在NK细胞和T细胞中，颗粒酶与 …

2015年5月22日 · In this Review, we discuss the current understanding of the structural, cellular and clinical aspects of perforin and granzyme biology.

Granzymes are a family of cytotoxic proteases that each act on unique sets of biological substrates within target cells, usually to induce cell death. Granzymes are differentially expressed within T cells, depending on their environment and activation state, making the granzyme cytotoxic pathway dynamic and responsive to individual circumstances.

Granzymes belong to the serine-protease family, and five human members have been identified: granzyme A (GA), granzyme B (GB), granzyme H (GH), granzyme M (GM) and granzyme K (GK) . Similarly, the mouse genome encodes numerous granzyme proteases (GA-G, K, M, and N) with cytotoxic potential, although they have different substrate specificity and ...

Granzyme A是CTL和NK细胞中较为丰富的蛋白酶。 它通过穿孔素进入到靶细胞，进而诱导caspase非依赖性的细胞死亡。 被赖氨酰肽链内切酶激活后，Granzyme A就会裂解硫酯底物。

颗粒酶A（Granzyme A，GzmA）是一种丝氨酸蛋白酶，主要定位于活化淋巴细胞和自然杀伤（NK）细胞的胞质中。 它是细胞毒性颗粒中表达丰度最高的蛋白酶之一，具有多种重要的生物学功能。

Chowdhury D, Beresford PJ, Zhu P, et al.(2006) The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death. Mol Cell 23(1):133-42.

2010年1月15日 · Whereas granzyme A may promote target cell death through multiple pathways, proteolysis of components of the endoplasmic reticulum-associated SET complex has been proposed to constitute the main...