Grb2 is best known for its ability to link the epidermal growth factor receptor tyrosine kinase to the activation of Ras and its downstream kinases, ERK1,2. Grb2 is composed of an SH2 domain flanked on each side by an SH3 domain .

Grb2蛋白 (growth factor receptor-bound protein 2)Grb2是生长因子受体结合蛋白2，又叫Ash蛋白，在人类中由Grb2基因编码。 该蛋白参与细胞内各种受体激活后的下游调节。 它能够直接与激活的 表皮生长因子受体 磷酸化的酪氨酸结合,参与EGF受体介导的信号转导,也能通过与Shc磷酸化的 酪氨酸 结合间接参与由 胰岛素受体介导的信号转导。 Grb2能够同时与Shc、Sos结合形成Shc-Grb2-Sos复合物,并将Sos激活，激活的Sos与质膜上的Ras蛋白结合，并将其激活,引起 信号级 …

2024年12月25日 · GRB2 (Growth Factor Receptor Bound Protein 2) is a Protein Coding gene. Diseases associated with GRB2 include Hepatitis C and Hepatitis E. Among its related pathways are Downstream signaling of activated FGFR2 and Prolactin Signaling. Gene Ontology (GO) annotations related to this gene include RNA binding and protein kinase binding.

The growth factor receptor-bound protein-2 (GRB2) is essential for multiple cellular functions. Inhibition of GRB2 function impairs developmental processes in various organisms and blocks transformation and proliferation of various cell types. GRB2 is …

2025年3月4日 · GRB2 is an adaptor protein that plays a role in cell signal transduction. Here, the authors reveal an attenuation of GRB2 in endometrium from infertile women and show GRB2 knockout in mice results ...

Growth-factor-receptor-binding protein 2 (GRB2) is a non-enzymatic adaptor protein that plays a pivotal role in precisely regulated signaling cascades from cell surface receptors to cellular responses, including signaling transduction and gene ...

2024年2月22日 · Growth-factor-receptor-binding protein 2 (GRB2) is a non-enzymatic adaptor protein that plays a pivotal role in precisely regulated signaling cascades from cell surface receptors to cellular responses, including signaling transduction and gene expression.

2024年9月1日 · GRB2, or Growth Factor Receptor-Bound Protein 2, is a pivotal adaptor protein in intracellular signal transduction pathways, particularly within receptor tyrosine kinase (RTK) signaling cascades.

生长因子受体结合蛋白2（growth factor receptor bound protein 2,Grb2）是一种在细胞中广泛表达的衔接蛋白。 作为信号通路上的节点蛋白,Grb2在细胞内许多信号传导通路中起着重要调控作用。

GRB2 is a BECN1 interacting protein that regulates autophagy. Preosteoclast plays a pathogenic role in syndesmophyte formation of ankylosing spondylitis through the secreted PDGFB - GRB2/ERK/RUNX2 pathway. GRB2 serves as a viable target against skin fibrosis in systemic sclerosis by regulating endothelial cell apoptosis.