Grb2 depletion under non-stimulated conditions inhibits PTEN
2015年7月27日 · We show that the decrease in PI (4,5)P 2 level under non-stimulated conditions inhibits PTEN activity leading to the aberrant activation of the oncoprotein Akt. This results in …
GRB2: A pivotal protein in signal transduction - ScienceDirect
2001年10月1日 · GRB2 regulates ERK1.2 and AKT activity in EGFR- and HER2/neu-overexpressing cells, respectively, yet GRB2 regulates the activity of both ERK1.2 and AKT in …
GRB2 regulation of essential signaling pathways in the ... - Nature
2025年3月4日 · GRB2 binds to EGFR for various biological processes by activating PI3K/AKT and ERK/MAPK pathways 16,17. Our RNA-seq analysis identified 246 dysregulated EGFR …
GRB2: A dynamic adaptor protein orchestrating cellular signaling …
2024年9月1日 · GRB2 is Crucial in cellular signaling pathways. Insights into structural and functional features of GRB2. Dynamic interplay between domains drive GRB2 function. …
The Configuration of GRB2 in Protein Interaction and Signal
2024年2月22日 · Furthermore, GRB2 also plays a crucial role in linking RTK to phosphatidylinositol-3-kinase (PI3K)/serine protein kinase AKT (PI3K/AKT) signaling . The c …
Grb2, a Double-Edged Sword of Receptor Tyrosine Kinase Signaling
Grb2 is conventionally known for playing positive roles in RTK signaling. The discovery of a negative regulatory role for Grb2 reveals that this adaptor acts as a double-edged sword in the …
Grb2 downregulation leads to Akt inactivation in heregulin
2000年12月14日 · Akt was inactivated following Grb2 downregulation in heregulin-stimulated breast cancer cells. We then examined the effects of Grb2 downregulation on Akt in ErbB2 …
Inhibition of bone morphogenetic protein receptor 2 suppresses ...
By carrying out protein mass spectrometry technique as well as bioinformatics analysis, we identified that BMPR2 regulated the growth factor receptor-bound protein …
GRB2: a pivotal protein in signal transduction - PubMed
The growth factor receptor-bound protein-2 (GRB2) is essential for multiple cellular functions. Inhibition of GRB2 function impairs developmental processes in various organisms and blocks …
Grb2 depletion under non-stimulated conditions inhibits PTEN ... - PubMed
2016年4月28日 · We show that the decrease in PI (4,5)P2 level under non-stimulated conditions inhibits PTEN activity leading to the aberrant activation of the oncoprotein Akt. This results in …